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TranscriptomicsAlternative splicing is frequent during early embryonic development in mouse
Background Alternative splicing is known to increase the complexity of mammalian transcriptomes since nearly all mammalian genes express multiple pre-mRNA isoforms. However, our knowledge of the extent and function of alternative splicing in early embryonic development is based mainly on a few isola...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21971 | biostudies-arrayexpress
GenomicsGenome-wide maps of nucleosome occupancy in human lymphoblastoid cell lines
Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to assess due to the limited resolution of existing ...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-36979 | biostudies-arrayexpress
TranscriptomicsThe contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels
Analysis of the extent to which inter-individual variation in mRNA decay contributes to inter-individual variation in gene expression levels in humans. The study examines properties of genome-wide decay rates and the relationship between mRNA decay and gene expression across genes, across individual...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-37451 | biostudies-arrayexpress
GenomicsEGAS00001000367-sc-20130612 - samples
In order to progress human induced pluripotent stem cells (hiPSCs) towards the clinic, several outstanding questions must be addressed. It is possible to reprogram different somatic cell types into hiPSCs and from studies in the mouse, it appears that an epigenetic memory of the starting cell type ...
EGAD00001000604 | EGA
GenomicsAssessment of genetic and epigenetic variation in human IPS cells RNA
In order to progress human induced pluripotent stem cells (hiPSCs) towards the clinic, several outstanding questions must be addressed. It is possible to reprogram different somatic cell types into hiPSCs and from studies in the mouse, it appears that an epigenetic memory of the starting cell type ...
EGAS00001000367 | EGA
GenomicsInternational Consortium on the Genetics of Systemic Lupus Erythematosus (SLEGEN)

The genetic makeup of an individual strongly influences the risk of developing systemic lupus erythematosus (SLE). The identification of genes that predispose an individual to SLE will lead to earlier and better diagnosis, better treatments, and possibly prevention.

To this end, t...

phs000216.v1.p1 | EGA
GenomicsOMRF SLEGEN GWAS Data from European-American Women with Lupus

"Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with complex etiology but strong clustering in families (lambda(S) = approximately 30). We performed a genome-wide association scan using 317,501 SNPs in 720 women of European ancestry with SLE and in 2,337 controls,...

phs000202.v1.p1 | EGA
GenomicsVariation in chromatin accessibility is a key determinant of heritable variation in gene expression
While it is well established that variation in gene expression levels can be influenced by single nucleotide polymorphisms (SNPs), little is known about the regulatory mechanisms by which this occurs. To address this gap, we used DNaseI sequencing to measure genome-wide chromatin accessibility in 70...
ORGANISM(S): Homo sapiens 
2012-01-26 | E-GEOD-31388 | biostudies-arrayexpress
ProteomicsHipSci project proteomics batch 1, comprising 6 IPS cell lines from 3 donors
The Human Induced Pluripotent Stem Cells Initiative (HipSci) is generating a large, high-quality reference panel of human IPSC lines. This is a submission of mass-spectrometry analyses from 6 induced pluripotent stem cell lines generated by the HipSci project.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-15 | MSV000081088 | MassIVE
ProteomicsHipSci project pilot submission for 18 IPS cell lines
The Human Induced Pluripotent Stem Cells Initiative (HipSci) is generating a large, high-quality reference panel of human IPSC lines. This is a pilot submission of mass-spectrometry analyses from 18 induced pluripotent stem cell lines generated by the HipSci project. This submission includes also da...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-24 | MSV000080004 | MassIVE
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