Sort   by:  
 Page size 
ProteomicsNGLY1 mutations cause protein aggregation in human neurons
Biallelic mutations in the gene that encodes the enzyme N-glycanase 1 (NGLY1) cause a rare disease with multi-symptomatic features including developmental delay, intellectual disability, neuropathy and seizures. NGLY1’s activity in human neural cells is currently not well understood. To understand h...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD031091 | Pride
Forebrain organoids Fragmented mitochondria Heat shock proteins Protein aggregates Ngly1 deficiency Neural cells 
TranscriptomicsComparing Control and Schizophrenic hiPSC-derived Neurons
Schizophrenia is a debilitating neurological disorder for which no cure exists. Few defining characteristics of schizophrenic neurons have been identified and the molecular mechanisms responsible for schizophrenia are not well understood, in part due to the lack of patient material for study. Human ...
ORGANISM(S): Homo sapiens 
2011-05-01 | E-GEOD-25673 | biostudies-arrayexpress
TranscriptomicsModeling human brain evolution using induced pluripotent stem cells: comparative analysis of neuronal development in humans and chimpanzees
Understanding evolutionary mechanisms underlying expansion and reorganization of the human brain represents an important aspect in analyzing the emergence of cognitive abilities typical of our species. Comparative analyses of neuronal phenotypes in closest living relatives (Pan troglodytes; the comm...
ORGANISM(S): Pan troglodytes 
2016-08-07 | E-GEOD-83638 | biostudies-arrayexpress
TranscriptomicsGenetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource
The Hippocampus Consortium data set provides estimates of mRNA expression in the adult hippocampus of 99 genetically diverse strains of mice including 67 BXD recombinant inbred strains, 13 CXB recombinant inbred strains, a diverse set of common inbred strains, and two reciprocal F1 hybrids. The hipp...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-84767 | biostudies-arrayexpress
Proteomics5HT - Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3
we provide evidence for a new class of histone posttranslational modification (PTM): serotonylation.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-04 | MSV000093567 | MassIVE
Sort   by:  
 Page size