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TranscriptomicsEffect of PML/RARA on the transcriptome of preleukemic early promyelocytes vs PML/RARA-Flt3ITD leukemic promyelocytes
Transcriptional profiling of murine cells expressing PML/RARA at the early promyelocyte stage (4 weeks old, preleukemic) and in full blown PML/RARA leukemia generated by transducing PML/RARA bone marrow with a Flt3-ITD retroviral vector Two-conditions experiment: preleukemic early promyelocytes vs l...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-59431 | biostudies-arrayexpress
GenomicsThe ability of PML/RARα to initiate leukemia is associated with markedly increased proliferation of promyelocytes despite minor changes in the transcriptome and epigenome.
Acute Promyelocytic Leukemia is characterized by the accumulation in the blood and bone marrow of promyelocytes. The PML/RARα fusion protein is identified as the primary abnormality implicated in the pathology, and is believed to prevent transcription of genes necessary for normal myeloid developmen...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-54038 | biostudies-arrayexpress
TranscriptomicsEffect of PML/RARa on the transcriptome of maturing myeloid populations in vivo
Transcriptional profiling of murine cells at the GMP, Early promyelocyte (Early Pros) and Late promyelocyte (Late Pros) stages, isolated from Wt or MRP8-PML/RARa transgenics after 2 rounds of sorting. Two-conditions experiment: Wt vs PML/RARa. 3 populations: GMP, Early Pros, Late Pros. 3-4 biologica...
ORGANISM(S): Mus musculus 
2015-06-24 | E-GEOD-54474 | biostudies-arrayexpress
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