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Post-Radiotherapy GSCs EGR1-Induced GAL3 Upregulation and T Cell Exhaustion in GBM
Background: Glioblastoma (GBM), a highly aggressive brain cancer, inevitably recurs due to therapy-resistant glioblastoma stem cells (GSCs). Lymphocyte activation gene 3 (LAG3) contributes to T cell exhaustion, a key immune escape mechanism. Here, we investigate that the more exhausted state of GBM-...
ORGANISM(S): Homo sapiens 
2025-04-20 | GSE294744 | GEO
Genomics
Tumor Cell-derived LIF and Gal3 Hijack Neural Signals to Promote Cancer Proliferation
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