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MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
MetabolomicsLow-Protein Diet Enhances Anti-Tumor Immunity in Pancreatic Cancer through Microbiota-Derived Uridine Diphosphate-Galactose
Low-protein diets (LPD) have been linked to improved metabolic health, but their role in pancreatic ductal adenocarcinoma (PDAC) immunotherapy remains unclear. Here we show that an LPD suppresses PDAC progression in male mice by remodeling the gut microbiota and activating anti-tumor immunity. LPD p...
2026-07-09 | MTBLS14989 | MetaboLights
MetabolomicsAtractylodin targets ASAH3L to regulate galactose metabolism and thereby modulates the HIF-1 signaling pathway for the treatment of acute lung injury

Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) is the main active component of Atractylodes lancea (Thunb.) DC., which has good anti-inflammatory activity and protects the integrity of the epith...

2024-07-23 | MTBLS9948 | MetaboLights
TranscriptomicsTranscription profiling of galactose-grown S. cerevisiae cells exposed to lithium chloride
Wild type strain CEN.PK113-7D was grown in an aerobic batch cultivation with a start concentration of 20 g/L galactose. During exponential growth at a biomass concentration of 3 g dry weight/L LiCl was added to a concentration of 10 mM. Just before addition of LiCl (time 0) and 20, 40, 60 and 140 mi...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-461 | biostudies-arrayexpress
TranscriptomicsGalactose Vs Glucose
Comparison of the Streptococcus pneumoniae D39 wild type in M17 medium+ 0.5 % (w/v) Galactose (GaM17) compared to M17 medium+ 0.5 % (w/v) Glucose (GM17) Two condition design comparison of Wild-type strain including a dye swap
ORGANISM(S): Streptococcus pneumoniae D39 
2014-06-20 | E-GEOD-58180 | biostudies-arrayexpress
TranscriptomicsSystem level characterization of galactose mutants of yeast
Adaptively evolved mutants of yeast on galactose were characterized by feremtation physiology and tools from systems biology. Three evolved mutants of yeast grown on aerobic batch with galactose as carbon source
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-31 | E-GEOD-27185 | biostudies-arrayexpress
MetabolomicsHuman NK vs T cell metabolism using 13C-Glucose tracer with/out galactose (part II)
Not available
ORGANISM(S): Homo sapiens 
ST000950 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of wild type, GALT-deficient and GALT-deficient-revertant yeast grown on media with galactose or glucose
To better understand the pathophysiology of galactose-1-phosphate uridyltransferase (GALT) deficiency in humans, we studied the mechanisms by which a GALT-deficient yeast survived on galactose medium. Under normal conditions, GALT-deficient yeast cannot grow in medium that contains 0.2% galactose as...
ORGANISM(S): Saccharomyces cerevisiae 
2008-04-10 | E-MEXP-1420 | biostudies-arrayexpress
TranscriptomicsThe role of the transcription factors LacR and LacT in the regulation of the lactose and galactose utilization pathways in Streptococcus pneumoniae
Abstract: Transcriptome comparison of the Streptococcus pneumoniae strain D39 grown in the presence of either lactose or galactose with that of the strain grown in the presence of glucose, revealed the elevated expression of various genes and operons, including the lac gene cluster that is organized...
ORGANISM(S): Streptococcus pneumoniae D39 
2014-06-20 | E-GEOD-58184 | biostudies-arrayexpress
MetabolomicsHuman NK vs T cell metabolism using 13C-Glucose tracer with/out oligomycin and galactose (part IV)
Not available
ORGANISM(S): Homo sapiens 
ST000952 | MetabolomicsWorkbench
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