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Natural killer T (NKT) cells are important therapeutic targets in various disease models and under clinical trials for cancer patients. However, their function in obesity and type 2 diabetes remains unclear. Our data show that adipose tissues of both mice and humans contain a population of type-1 NK...
ORGANISM(S): Mus musculus 
The purpose of this study is to discern global expression programs embodying therapeutic targeting of CLN3 disease. Differential gene expression in Cln3Δex7/8 mouse brains was determined after intraperitoneal vehicle/Galactosylceramide (GalCer) injections, for 40 weeks, using GeneChip Mouse Genome 4...
ORGANISM(S): Mus musculus 
Transcriptional profiling of mouse iNKT cells comparing wild type and Bcl11b deficient cell. The mice were treated with 4 μg of α-galactosylceramide. Goal was to determine the effects of transcription factor Bcl11b removal in iNKT cells. Intraperitoneal treatment with 4 μg of α-Galactosylceram...
ORGANISM(S): Mus musculus 
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