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Transcriptomicsmedium vs cell miRNA
To investigate the inside and exported miRNA in cell culture system. We characterized the miRNA spectra of cell lines when deprived of serum. The absence of miRNAs present in bovine serum is a distinct advantage of using serum depletion to study extracellular miRNA as it removes potential source of ...
ORGANISM(S): Homo sapiens 
2011-04-23 | E-GEOD-21533 | biostudies-arrayexpress
TranscriptomicsAffect of liver transcriptome by acute acetaminophen exposure [mRNA]
To study the global changes of liver transcriptome after acetaminophen overdose. To study the global changes of transcriptome in the liver after acetaminophen overdose. Eight week old female C57BL/6 mice were fasted for 24 hours prior to a single intraperitoneal injection of 350mg/kg of acetaminoph...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-42178 | biostudies-arrayexpress
TranscriptomicsAffect of liver transcriptome by acute acetaminophen exposure [miRNA]
To study the global changes of liver transcriptome after acetaminophen overdose. To study the global changes of transcriptome in the liver after acetaminophen overdose. Eight week old female C57BL/6 mice were fasted for 24 hours prior to a single intraperitoneal injection of 350mg/kg of acetaminoph...
ORGANISM(S): Mus musculus 
2013-05-03 | E-GEOD-42181 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21369 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-21394 | biostudies-arrayexpress
TranscriptomicsGene expression networks in COPD: microRNA and mRNA regulation
70 miRNAs and 2667 mRNAs were differentially expressed between lung tissue from subjects with COPD and smokers without COPD. miRNA and mRNA expression profiles enriched for biological pathways that may be relevant to the pathogenesis of COPD including the transforming growth factor b, Wnt and focal ...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-38974 | biostudies-arrayexpress
GenomicsGenetic Analysis of Limb Malformation Disorders: Miller Syndrome Sequencing Study (LMD-MS)

The overall goal of this project is to investigate the etiology and pathogenesis of malformations (i.e., birth defects) of the limb, concentrating on abnormalities of limb patterning such as limb deficiency/duplications and multiple congenital contractures.

The exome sequences of two s...

phs000244.v1.p1 | EGA
TranscriptomicsGene expression signatures in heart tissues of mice simulating posttraumatic stress disorder (PTSD) [Study1]
Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation We designed our initial study (Study I) with four experimental conditions where we varied the length of time that subservient mice were exposed to aggr...
ORGANISM(S): Mus musculus 
2013-12-04 | E-GEOD-52866 | biostudies-arrayexpress
TranscriptomicsYeast (Saccharomyces cerevisiae) Overexpression suppression study
To address the mechanisms of suppression, we analyzed time course of mRNA expression of four suppressed smc2-8 mutant strains. We addressed the question of genomic robustness by systematically screening genomic open reading frames, when induced for high-level expression, for their ability to suppres...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-20 | E-GEOD-24266 | biostudies-arrayexpress
UnknownrmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
Not available
S-EPMC3028771 | biostudies-literature
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