Sort   by:  
 Page size 
MetabolomicsUntargeted Serum Metabolomics Reveals Differential Signatures in Gallstone-Associated and Gallstone-Free Gallbladder Cancer

Gallbladder cancer (GBC) is an aggressive malignancy often associated with gallstones (GBCGS), a condition distinct from gallstone disease (GSD). Both GBC and GBCGS are rare, with unclear pathogenesis and no established biomarker-based solutions. This pilot study aimed to identify distinct metabo...

2025-12-22 | MTBLS12514 | MetaboLights
MetabolomicsGallbladder microbial species and host bile acids biosynthesis linked to cholesterol gallstone comparing to pigment individuals

Gallstones are crystalline deposits in the gallbladder that are traditionally classified as cholesterol, pigment or mixed stones based on their composition. Microbiota and host metabolism variances among the different types of gallstones remain largely unclear. Here, the bile and gallstone microb...

2024-03-11 | MTBLS7736 | MetaboLights
TranscriptomicsIdentification of circulating lncRNAs associated with gallbladder cancer risk by tissue-based preselection, cis-eQTL validation, and analysis of association with genotype-based expression
Long non-coding RNAs (lncRNAs) play key roles in cell processes and are good candidates for cancer risk prediction. Few studies have investigated the association between individual genotypes and lncRNA expression. Here we integrate three separate datasets with information on lncRNA expression only, ...
ORGANISM(S): Homo sapiens 
2022-01-17 | E-MTAB-11367 | biostudies-arrayexpress
ProteomicsQuantitative proteomic analysis of gallbladder cancer
We carried out an iTRAQ-based quantitative proteomic analysis of gallbladder cancer and adjacent non-tumor tissue to systematically identify differentially expressed proteins in gallbladder cancer. Ten gallbladder adenocarcinoma and ten adjacent non-tumor tissue samples were selected post pathologic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082884 | MassIVE
TranscriptomicsMethylation analysis of Chilean patients with gallstone disesase, low- or high-grade gallbladder dysplasia or gallbladder cancer
Epigenome-wide methylation levels were measured in patients from Chiel with gallstone disease, gallbladder dyplasia or gallbladder cancer using Illumina Infinium methylation arrays.
ORGANISM(S): Homo sapiens 
2020-12-12 | E-MTAB-9868 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNAs and mRNAs expression analysis of gallbladder cancer
Although many protein-coding genes have been identified to be aberrantly expressed in gallbladder cancer, the mechanism that account for the development and progression of gallbladder cancer remains unclear. In recent years, long noncoding RNAs have been shown to play vital roles in mammalian cell b...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-62335 | biostudies-arrayexpress
TranscriptomicsmicroRNAseq of primary human gallbladder cells, reprogrammed human gallbladder cells, and human pancreatic beta cells
We determined the global microRNA expression profiles of primary human gallbladder cells and genetically reprogrammed human gallbladder cells and compared with pancreatic beta cells to ascertain the degree of cellular transdifferentatiation of insulin-producing human gallbladder cells to become beta...
ORGANISM(S): Homo sapiens 
2017-08-02 | E-MTAB-5554 | biostudies-arrayexpress
TranscriptomicsRNAseq of primary human gallbladder cells, reprogrammed human gallbladder cells, and human pancreatic beta cells
We determined the global gene expression profiles of primary human gallbladder cells and genetically reprogrammed human gallbladder cells and compared with pancreatic beta cells to ascertain the degree of cellular transdifferentatiation of insulin-producing human gallbladder cells to become beta-lik...
ORGANISM(S): Homo sapiens 
2017-08-02 | E-MTAB-5556 | biostudies-arrayexpress
ProteomicsTranscriptome and phosphoproteome analyses of gemcitabine-resistant gallbladder cancer cells provide novel insights into molecular changes occurring during acquired resistance
Treatment options for advanced gallbladder cancer (GBC) are scarce and usually rely on cytotoxic chemotherapy, but unfortunately the effectiveness of any regimen is limited, and recurrence rates are high. Here, we established and characterized two gemcitabine-resistant GBC cell sublines (NOZ GemR an...
ORGANISM(S): Homo sapiens (Human) 
2023-05-03 | PXD036348 | Pride
Gemcitabine resistance Gallbladder cancer 
TranscriptomicsR-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders.
Pioneering studies within the last few years have allowed the in vitro expansion of tissue-specific adult stem cells from a variety of endoderm-derived organs, including the stomach, small intestine and colon. Here we derived organoids from mouse gallbladder tissue (gallbladder organoids), from mous...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-77461 | biostudies-arrayexpress
Sort   by:  
 Page size