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UnknownTemperature-induced melting of double-stranded DNA in the absence and presence of covalently bonded antitumour drugs: insight from molecular dynamics simulations.
Not available
S-EPMC3185422 | biostudies-literature
Unknownc-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity.
Not available
S-EPMC3707168 | biostudies-literature
UnknownMulticenter Phase II Study of Lurbinectedin in BRCA-Mutated and Unselected Metastatic Advanced Breast Cancer and Biomarker Assessment Substudy.
Not available
S-EPMC6209089 | biostudies-literature
UnknownInhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway.
Not available
S-EPMC3799600 | biostudies-literature
UnknownDual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.
Not available
S-EPMC5041952 | biostudies-literature
UnknownLurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models.
Not available
S-EPMC5572168 | biostudies-literature
UnknownThe PARP inhibitor olaparib enhances the sensitivity of Ewing sarcoma to trabectedin.
Not available
S-EPMC4662461 | biostudies-literature
UnknownIrvalec inserts into the plasma membrane causing rapid loss of integrity and necrotic cell death in tumor cells.
Not available
S-EPMC3083409 | biostudies-literature
UnknownPM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity.
Not available
S-EPMC2998690 | biostudies-literature
UnknownPhase II randomized study of PM01183 versus topotecan in patients with platinum-resistant/refractory advanced ovarian cancer.
Not available
S-EPMC5452066 | biostudies-literature
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