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MetabolomicsEnergy-stress-mediated AMPK activation inhibits ferroptosis

Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid peroxidation can be inhibited by treatment...

2023-01-31 | MTBLS1399 | MetaboLights
TranscriptomicsGene expression profiles in human kidney cancer cells in response to FoxO1 or FoxO3 activation
The mammalian FoxO transcription factors - FoxO1, FoxO3, FoxO4 - function in the nucleus to direct transcription of specific gene targets governing cellular survival, proliferation, metabolism, differentiation and oxidative defense. Activation of PI3K by extracellular growth factors leads to AKT-med...
ORGANISM(S): Homo sapiens 
2011-10-20 | E-GEOD-23926 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Lkb1 WT and KO hematopoietic stem cells (HSCs)
LKB1 encodes a Ser/Thr kinase and acts as an evolutionarily conserved sensor of cellular energy status in eukaryotic cells. LKB1 functions as the major upstream kinase to phosphorylate AMPK and 12 other AMPK-related kinases, which is required for their activation in many cellular contexts. Once acti...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-24765 | biostudies-arrayexpress
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