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TranscriptomicsStudy of the role of miR-205 in prostate epithelial cells
Gene expression has been assessed on RWPE-1 cells, derived from normal prostate, upon silencing of miR-205 by an antisense locked nucleic acid. RWPE-1 cells were transfected in triplicate either with 100nM of an antisense locked nucleic acid targeting miR-205 (LNA-205) or a scrambled oligomer (LNA-S...
ORGANISM(S): Homo sapiens 
2012-06-11 | E-GEOD-29782 | biostudies-arrayexpress
TranscriptomicsMesenchymal to amoeboid transition is associated with stem-like features of melanoma cells
Cellular plasticity confers cancer cells the ability to adapt to micro-environmental changes, a fundamental requirement for tumour progression and metastasis. The epithelial to mesenchymal transition (EMT) is a transcriptional programme associated with increased cell motility and stemness. Beside EM...
ORGANISM(S): Homo sapiens 
2014-04-22 | E-GEOD-52246 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression in prostate cancer cells stimulated with cancer associated fibroblasts
Tumor microenvironment is a strong determinant for the acquisition of metastatic potential of cancer cells. It has been demonstrated (Giannoni E et al., Cancer Res 2010) that cancer associated fibroblasts (CAF) elicit an epithelial-mesenchymal transition (EMT) in prostate cancer (PCa) cells, leading...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-42699 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in prostate cancer and non-neoplastic tissues
miRNA expression profiles were evaluated in a series of 64 prostate clinical specimens, including 32 cancer and 32 non-neoplastic tissues. For 26 individuals, paired cancer and non-neplastic tissue was available. Tumor and non-neoplastic tissues were obtained, with appropriate informed consent and I...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-76260 | biostudies-arrayexpress
TranscriptomicsIntegrated miRNA and gene expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation [gene]
Tumor microenvironment coevolves with and simultaneously sustains cancer progression. Reactive fibroblasts found in prostate cancer (PCa), known as cancer associated fibroblasts (CAF), have been indeed shown to fuel tumor development and metastasis by mutually interacting with PCa cells. Little is k...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-68164 | biostudies-arrayexpress
TranscriptomicsIntegrated miRNA and gene expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation [miRNA]
Tumor microenvironment coevolves with and simultaneously sustains cancer progression. Reactive fibroblasts found in prostate cancer (PCa), known as cancer associated fibroblasts (CAF), have been indeed shown to fuel tumor development and metastasis by mutually interacting with PCa cells. Little is k...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-68165 | biostudies-arrayexpress
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