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MetabolomicsMicrobial-derived Hyodeoxycholic Acid Ameliorates Painful Diabetic Neuropathy by Modulating Dorsal Root Ganglion TLR4-Mediated Neuroinflammation Signaling Pathway

BACKGROUND: Painful diabetic neuropathy (PDN) is characterized by hyperalgesia and neuronal hyperexcitability. Although gut microbiota dysbiosis have been found in PDN, how microbiota influences PDN remains largely unexplored. RESULTS: Gut microbiota and its metabolites impacted PDN was investiga...

2026-08-24 | MTBLS12087 | MetaboLights
TranscriptomicsSingle cell RNA sequencing of stem cell-derived retinal ganglion cells
We used human embryonic stem cell-derived retinal ganglion cells (RGCs) to characterize the transcriptome of 1,174 cells at the single cell level. The human embryonic stem cell line BRN3B-mCherry A81-H7 was differentiated to RGCs using a guided differentiation approach. Cells were harvested at day 3...
ORGANISM(S): Homo sapiens 
2017-10-07 | E-MTAB-6108 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression changes in rat retinal ganglion cells after experimental glaucoma
Goals of the study: 1. Assess the gene expression profile in rat RGC after experimental IOP elevation to elucidate the molecular mechanisms of RGC death. 2. Identify potentially novel genes and pathways that may contribute to RGC death in glaucoma. Background: Glaucoma is a neurodegenerative diseas...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-12596 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse developing retinal ganglion and amacrine cells reveals molecular heterogeneity of
During development of the central nervous system (CNS), cycling uncommitted progenitor cells give rise to a variety of distinct neuronal and glial cell types. As these different cell types are born, they progress from newly specified cells to fully differentiated neurons and glia. In order to defi...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9812 | biostudies-arrayexpress
TranscriptomicsRNAseq of A/J mice spiral ganglion derived neurospheres vs differentiated auditory neurons
Sphere-forming progenitor cells can be isolated from the fetal and adult mammalian inner ear and give rise to inner ear specific cell types in vitro. Here, we provide phenotypical and functional characterization of a new pool of auditory progenitors as sustainable source for sphere-derived auditory ...
ORGANISM(S): Mus musculus 
2020-08-29 | E-MTAB-9441 | biostudies-arrayexpress
TranscriptomicsTLR3, TLR7, and TLR9 stimulation in murine dorsal root ganglion neurons
TLR3, TLR7, and TLR9 stimulation induces many mouse inflammatory and autoimmune cytokines or immune receptors DRGN were cultures 5 days prior to a 16 hour stimulation - Three separate studies were analyzed for inflammatory response
ORGANISM(S): Mus musculus 
2011-03-02 | E-GEOD-27579 | biostudies-arrayexpress
ProteomicsInvestigating Autophagy Disruption Induces Neurodegeneration in Glaucoma OPTN(E50K) Retinal Ganglion Cells
Retinal ganglion cells (RGCs) are the sole projection neurons that connect the eye with the brain, and the degeneration of these cells in diseases such as glaucoma results in vision loss or blindness. Similar to other neurons throughout the central nervous system, RGCs are postmitotic and therefore ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD033173 | Pride
Autophagy Human pluripotent stem cell Retinal ganglion cells 
TranscriptomicsSubcellular expression profiling of the growth cones of retinal ganglion cells (RGC)
Cue-directed axon guidance depends partly on local translation in growth cones. Many mRNA transcripts are known to reside in developing axons yet little is known about their subcellular distribution or, specifically, which transcripts are in growth cones. Laser capture microdissection (LCM) was used...
ORGANISM(S): Xenopus laevis 
2010-11-23 | E-GEOD-25166 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of trigeminal ganglia of Brn3a knockout and wild type mice to determine the regulatory targets of transcription factor Brn3a.
Mice lacking the POU-domain transcription factor Brn3a exhibit marked defects in sensory axon growth and abnormal sensory apoptosis. We have determined the regulatory targets of Brn3a in the developing trigeminal ganglion using microarray analysis of Brn3a mutant mice. These results show that Brn3 m...
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-3895 | biostudies-arrayexpress
UnknownIdentification of retinal ganglion cell neuroprotection conferred by platelet-derived growth factor through analysis of the mesenchymal stem cell secretome.
Not available
S-EPMC3914467 | biostudies-literature
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