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GenomicsChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines
In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2) and is responsible for repressing target gene expression through methylation of histo...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40970 | biostudies-arrayexpress
TranscriptomicsEZH2 Inhibition as a Therapeutic Strategy for Lymphoma with EZH2 Activating Mutations
This SuperSeries is composed of the following subset Series: GSE40970: ChIP-seq analysis of H3K27me3 histone modification in EZH2 mutant and wild type DLBCL cell lines GSE40971: Gene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor GSE41239: Gene express...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40972 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of EZH2 mutant and wild type DLBCL cell lines treated with EZH2 inhibitor
We studied transcriptional changes by Affymetrix human microarrays in DLBCL cell lines as a result of treatment with GSK126, a potent, highly-selective, SAM-competitive, small molecule inhibitor of EZH2 In eukaryotes, epigenetic post-translational modification of histones is critical for regulation ...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-40971 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of two DLBCL cell lines upon shRNA mediated knockdown of EZH2
We studied transcriptional changes by Affymetrix human microarrays in 2 DLBCL cell lines as a result of shRNA mediated knockdown of EZH2. In eukaryotes, epigenetic post-translational modification of histones is critical for regulation of chromatin structure and gene expression. EZH2 is the catalytic...
ORGANISM(S): Homo sapiens 
2012-10-12 | E-GEOD-41239 | biostudies-arrayexpress
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