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ProteomicsOperation of a TCA cycle subnetwork in the mammalian nucleus
Nucleic acid and histone modifications critically depend on central metabolism for substrates and co-factors. Although a few enzymes related to the formation of these metabolites have been reported in the nucleus, the corresponding metabolic pathways are considered to function elsewhere in the cell....
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD022608 | Pride
Nucleus Metabolic pathways Proximity-biotinylation mass spectrometry Stable isotope metabolomics study 
MetabolomicsOperation of a TCA cycle subnetwork in the mammalian nucleus

Nucleic acid and histone modifications critically depend on tricarboxylic acid (TCA) cycle for substrates and co-factors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria. Here, we show that a part of the...

2022-06-15 | MTBLS2235 | MetaboLights
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