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UnknownAn effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.
Recently, the pharmaceutical industry has shifted to pursuing combination therapies that comprise more than one active ingredient. Interestingly, combination therapies have been used for more than 2500 years in traditional Chinese medicine (TCM). Understanding optimal proportions and synergistic mec...
S-EPMC3827340 | biostudies-literature
UnknownChinese Nian Gao Inspired Textured Janus Hydrogel for Body Signal Sensing and Human Machine Interaction.
Inspired by Chinese Nian Gao, a traditional food in China, a skin-like bio-hydrogel with asymmetric Janus adhesion and textured structures on its surface is fabricated via a one-pot strategy and is evaluated as electronic skin for sensing and human-machine interaction. The e-skin is constructed thro...
S-EPMC12561419 | biostudies-literature
UnknownIdentification and biological characteristics of <i>Fusarium tobaccum</i> sp. nov., a novel species causing tobacco root rot in Jilin Province, China.
Fusarium wilt of tobacco (FWT), caused by Fusarium spp., has emerged as a severe threat to tobacco production in China. In all, 132 isolates of Fusarium were isolated from tobacco and pathogenic to tobacco-causing FWT in Jilin Province, China. In this study, we identified 7 of 132 isol...
S-EPMC11619358 | biostudies-literature
UnknownChemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice.
Jie-Geng-Tang (JGT), a classic and famous traditional Chinese medicine (TCM) prescription composed of Platycodon grandiflorum (Jacq.) A. DC. (PG) and Glycyrrhiza uralensis Fisch. (GU), is well known for "clearing heat and relieving toxicity" and its ability to "diffuse the lung and relieve sore thro...
S-EPMC4992511 | biostudies-literature
UnknownInhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1.
Huang-Lian-Jie-Du-Tang (HLJDT), a traditional formula with four TCM herbs, has been used for hundred years for different diseases. The current study aimed to assess the inhibitory activity of HLJDT against H1N1 neuraminidase (NA-1), and identify potent NA-1 inhibitors from its plasma profile. The in...
S-EPMC5686190 | biostudies-literature
UnknownQing-Xin-Jie-Yu Granule attenuates myocardial infarction-induced inflammatory response by regulating the MK2/TTP pathway.

Context

Qing-Xin-Jie-Yu Granule (QXJYG) has shown promise in the treatment of myocardial infarction. However, the mechanism of action of QXJYG underlying its anti-inflammation remain unknown.

Objective

The study aimed to evaluate the effectiveness and mechanism of QXJYG in a mouse mod...
S-EPMC11849043 | biostudies-literature
UnknownEffect of Huang-Lian Jie-Du Decoction on Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Background: Type 2 diabetes mellitus (T2DM) is a heterogeneous disease characterized by persistent hyperglycemia. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine formula which is widely used in treating T2DM in China. A thorough understanding of current body of evidence ...
S-EPMC8117159 | biostudies-literature
UnknownPharmacokinetic-Pharmacodynamic Analysis on Inflammation Rat Model after Oral Administration of Huang Lian Jie Du Decoction.
Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula with heat-dissipating and detoxifying effects. It is used to treat inflammation-associated diseases. However, no systematic pharmacokinetic (PK) and pharmacodynamic (PD) data concerning the activity of HLJD...
S-EPMC4900566 | biostudies-literature
UnknownQu-Du-San-Jie decoction induces growth inhibition and vascular normalization in NF2-associated vestibular schwannoma.
Background: Neurofibromatosis type 2 (NF2) is a rare genetic syndrome that predisposes individuals to develop bilateral vestibular schwannomas (VSs) causing a high risk of life-threatening neurological complications. Traditional treatment options for NF2-associated VS usually cause neurologic...
S-EPMC9437245 | biostudies-literature
UnknownSingle amino acid mutation of SR-BI decreases infectivity of hepatitis C virus derived from cell culture in a cell culture model.

Aim

To investigate the effect of a single amino acid mutation in human class B scavenger receptor I (SR-BI) on the infectivity of cell culture-derived hepatitis C virus (HCVcc) in SR-BI knock-down Huh7-siSR-BI cells.

Methods

Site-directed mutagenesis was used to construct the SR-BI S1...
S-EPMC5537182 | biostudies-literature
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