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ProteomicsPIP2 promotes MLKL-derived pathogenic process through enhancing its channel activity
PIP2 enhances MLKL channel activity in a direct interaction manner and this gain of function promotes both necroptosis and inflammation. Previous studies have reported that phospholipids assisted MLKL recruitment and translocation which facilitates its mediated function like liposome leaking. Here, ...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-05 | PXD030814 | Pride
Bv2 lps mlkl lc/msms pip2 
ProteomicsThe critical role of MLKL in hemorrhagic stroke and the therapeutic potential of its associated protein network
MLKL, as the executor of necroptosis and a critical factor in the inflammation, has been shown to be associated with the progression of hemorrhagic stroke. Studies identified MLKL is a promoting factor in this process, suggesting its potential as a therapeutic target to mitigate post-hemorrhagic str...
ORGANISM(S): Mus Musculus 
2024-09-27 | PXD056595 |
UnknownHistopathological Injuries, Ultrastructural Changes, and Depressed TLR Expression in the Small Intestine of Broiler Chickens with Aflatoxin B₁.
Not available
S-EPMC5923297 | biostudies-literature
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