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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
UnknownImmediate versus delayed frozen embryo transfer in women following a failed IVF-ET attempt: a multicenter randomized controlled trial.
Not available
S-EPMC8404351 | biostudies-literature
UnknownDifferent reactive profiles of calmodulin in the CSF samples of Chinese patients of four types of genetic prion diseases.
Not available
S-EPMC10881788 | biostudies-literature
UnknownCatalytic asymmetric dearomatization of phenols via divergent intermolecular (3 + 2) and alkylation reactions.
Not available
S-EPMC10457327 | biostudies-literature
UnknownMultilayer nonlinear diffraction neural networks with programmable and fast ReLU activation function.
Not available
S-EPMC12644553 | biostudies-literature
ProteomicsProteomic Characterization of Epithelial Ovarian Cancer Delineates Molecular Signatures and Therapeutic Targets in Distinct Histological Subtypes
Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear. Here, we undertake comprehensive proteomic profiling of 80 CCC, 79 EC, 80 SC, and 30 contr...
ORGANISM(S): Homo sapiens (Human) 
2023-10-30 | PXD033741 | Pride
Epithelial ovarian cancer proteomics histological subtype tumor biomarkers drug target 
ProteomicsTMT-labeled quantitative protein profiling of hippocampus during human aging
Human hippocampus is one of the critical brain regions affected by aging. However, a fully understanding of aging-related changes in protein profiles in human hippocampus has not been well described, especially for the Chinese population. With the newly founded human brain bank in Chinese Academy of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080710 | MassIVE
UnknownThe genetic diversity and population structure of domestic Aedes aegypti (Diptera: Culicidae) in Yunnan Province, southwestern China.
Not available
S-EPMC5470206 | biostudies-literature
UnknownNorepinephrine-Induced Stimulation of Kir4.1/Kir5.1 Is Required for the Activation of NaCl Transporter in Distal Convoluted Tubule.
Not available
S-EPMC6319266 | biostudies-literature
UnknownR229I substitution from oseltamivir induction in HA1 region significantly increased the fitness of a H7N9 virus bearing NA 292K.
Not available
S-EPMC467099 | biostudies-literature
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