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Elaiophylin was screened and identified as a novel autophagy inhibitor, with significant antitumor efficacy as a single agent. To explore the mechanisms by which elaiophylin kills cancer cells, NimbleGen 12x135K microarrays were used to find the gene expression changes in SKOV3 cells treated with el...
ORGANISM(S): Homo sapiens 
2022-06-07 | GSE205529 | GEO

The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
Leucine, as a branched amino acid, is not only a substrate for protein synthesis, but also a signaling molecule that affects many biological processes. Lysine crotonylation is a novel post-translational modification in both histone and non-histone proteins. What effect amino acids have on crotonylat...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD018118 | Pride
Metabolic profiling in COVID-19 patients has been associated with disease severity, but there is no report on sex-specific metabolic changes in discharged survivors. Herein we used an integrated approach of LC-MS-and GC-MS-based untargeted metabolomics to analyze plasma metabolic characteristics in ...
2022-01-10 | MTBLS2224 | MetaboLights
RNA sensing is critical for RLR activation and downstream signaling. To identify molecules that are involved in modulating viral RNA recognition, we utilized biotin-labeled 60 nt single-stranded RNA (ssRNA) from SARS-CoV-2 NSP1 coding region (NSP1 ssRNA) to pull down proteins from RAW264.7 cells. Th...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-08 | PXD064808 | Pride
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