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TranscriptomicsLapatinib and retinoic acid combination treatment of SKBR3 breast cancer cells
SKBR3 cells, which bear both an HER2 and a RARA gene amplification, were treated for 12 or 48 hours with 100 nM retinoic acid, 100 nM lapatinib or the combination.The two drugs synergize and induce massive apoptosis. The aim is to find the molecular mechanism(s) of this synergism. Gene expression pr...
ORGANISM(S): Homo sapiens 
2011-10-06 | E-MEXP-3192 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of F9 teratocarcinoma sublines characterized by the presence or absence of the RAR gamma nuclear retinoic acid receptor treated with trans retinoic acid and the novel retinoid, ST1926
Effect of all trans retinoic acid and the novel retinoid, ST1926, on the profile of gene expression in F9 teratocarcinoma sublines characterized by the presence or absence of the RAR gamma nuclear retinoic acid receptor
ORGANISM(S): Mus musculus 
2005-12-31 | E-MEXP-361 | biostudies-arrayexpress
TranscriptomicsSensitivity of gastric cancer cells to all-trans retinoic acid, a new agent in the personalized treatment of this heterogeneous tumor: definition of a predictive gene-expression model that may be used for the selection of patients who may benefit from retinoid-based treatments
All-trans retinoic acid (ATRA) is used in the treatment of Acute Promyelocytic Leukemia (APL) with exceptional results, inducing long-lasting remissions in 78% of the patients. In previous studies (Bolis M et al., Ann Oncol. 2017, 28:611; Centritto F et al., EMBO Mol Med. 2015, 7:950) we demonstrate...
ORGANISM(S): Homo sapiens 
2023-06-14 | E-MTAB-12385 | biostudies-arrayexpress
TranscriptomicsSensitivity of gastric cancer cells to all-trans retinoic acid, a new agent in the personalized treatment of this heterogeneous tumor: definition of a predictive gene-expression model that may be used for the selection of patients who may benefit from retinoid-based treatments (Xenografts)
All-trans retinoic acid (ATRA) is used in the treatment of Acute Promyelocytic Leukemia (APL) with exceptional results, inducing long-lasting remissions in 78% of the patients. In previous studies (Bolis M et al., Ann Oncol. 2017, 28:611; Centritto F et al., EMBO Mol Med. 2015, 7:950) we demonstrate...
ORGANISM(S): Homo sapiens 
2023-06-14 | E-MTAB-12394 | biostudies-arrayexpress
TranscriptomicsSensitivity of gastric cancer cells to all-trans retinoic acid, a new agent in the personalized treatment of this heterogeneous tumor: definition of a predictive gene-expression model that may be used for the selection of patients who may benefit from retinoid-based treatments (Cell Lines)
All-trans retinoic acid (ATRA) is used in the treatment of Acute Promyelocytic Leukemia (APL) with exceptional results, inducing long-lasting remissions in 78% of the patients. In previous studies (Bolis M et al., Ann Oncol. 2017, 28:611; Centritto F et al., EMBO Mol Med. 2015, 7:950) we demonstrate...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-12387 | biostudies-arrayexpress
TranscriptomicsAll trans-retinoic acid (ATRA) effect on triple negative (TNBC) and luminal (LumA/LumB) primary breast tumors
We performed whole genome gene expression microarrays on short-term cultures of mammary tumors deriving from diagnostic Tru-cut procedures of 16 patients in order to evaluate transcriptional response to the retinoid. Tissue slices were challenged with vehicle (DMSO) or ATRA 0.1åµm for 48 hours. The ...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-MTAB-3313 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation associated with chromatin accessibility of iPSC and hepatocytes derived from a Cornelia de Lange syndrome patient (RNA-Seq)
Cornelia de Lange syndrome (CdLS) is a rare genetic disease associated with cohesinopathy. A novel iPSC line was generated from the CdLS patient carrying a heterozygous missense point-mutation of the NIPBL gene. iPSC lines prepared from the healthy parents and the mutation-corrected isogenic cel...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-12631 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation associated with chromatin accessibility of iPSC and hepatocytes derived from a Cornelia de Lange syndrome patient (ATAC-Seq - D22)
Cornelia de Lange syndrome (CdLS) is a rare genetic disease associated with cohesinopathy. A novel iPSC line was generated from the CdLS patient carrying a heterozygous missense point-mutation of the NIPBL gene. iPSC lines prepared from the healthy parents and the mutation-corrected isogenic cel...
ORGANISM(S): Homo sapiens 
2023-06-15 | E-MTAB-12661 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation associated with chromatin accessibility of iPSC and hepatocytes derived from a Cornelia de Lange syndrome patient (ATAC-Seq - D9)
Cornelia de Lange syndrome (CdLS) is a rare genetic disease associated with cohesinopathy. A novel iPSC line was generated from the CdLS patient carrying a heterozygous missense point-mutation of the NIPBL gene. iPSC lines prepared from the healthy parents and the mutation-corrected isogenic cel...
ORGANISM(S): Homo sapiens 
2023-06-23 | E-MTAB-12684 | biostudies-arrayexpress
GenomicsTranscriptional dysregulation associated with chromatin accessibility of iPSC and hepatocytes derived from a Cornelia de Lange syndrome patient (WGS)
Cornelia de Lange syndrome (CdLS) is a rare genetic disease associated with cohesinopathy. A novel iPSC line was generated from the CdLS patient carrying a heterozygous missense point-mutation of the NIPBL gene. iPSC lines prepared from the healthy parents and the mutation-corrected isogenic cel...
ORGANISM(S): Homo sapiens 
2023-06-23 | E-MTAB-12691 | biostudies-arrayexpress
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