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TranscriptomicsTranscriptomic signature induced in bone marrow Mesenchymal Stromal Cells (MSC) after interaction with malignant multiple myeloma cells: implications in myeloma progression.
Mesenchymal stromal cells (MSCs) derived from the BM of healthy donors (dMSCs) and myeloma patients (pMSCs) were co-cultured with the model myeloma cell line - MM.1S -, and the gene expression profile of MSCs induced by this interaction was analyzed using high density oligonucleotide microarrays. De...
ORGANISM(S): Homo sapiens 
2014-11-23 | E-GEOD-46053 | biostudies-arrayexpress
UnknownMultiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics.
Not available
S-EPMC4131274 | biostudies-literature
TranscriptomicsCD20 positive cells are undetectable in the majority of multiple myeloma cell lines and are not associated with a cancer stem cell phenotype
Although new therapies have doubled the survival of multiple myeloma (MM) patients, this remains an incurable disease. It has been postulated that the so-called MM Cancer Stem Cells (MM-CSC) would be responsible for tumor initiation and relapse but their unequivocal identification remains unclear. H...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-33020 | biostudies-arrayexpress
TranscriptomicsPhenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines (Copy Number)
Despite recent advances in the treatment of multiple myeloma (MM), it remains an incurable disease potentially due to the presence of resistant myeloma cancer stem cells (MM-CSC). Although the presence of clonogenic cells in MM was described more than 30 years ago, the phenotype of MM-CSC is still a...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-49483 | biostudies-arrayexpress
TranscriptomicsPhenotypic, genomic and functional characterization reveals no differences between CD138++ and CD138low subpopulations in multiple myeloma cell lines
Despite recent advances in the treatment of multiple myeloma (MM), it remains an incurable disease potentially due to the presence of resistant myeloma cancer stem cells (MM-CSC). Although the presence of clonogenic cells in MM was described more than 30 years ago, the phenotype of MM-CSC is still a...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-49482 | biostudies-arrayexpress
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