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UnknownPhase II study of gemcitabine, carboplatin, and bevacizumab in patients with advanced unresectable or metastatic urothelial cancer.
Not available
S-EPMC3574268 | biostudies-literature
UnknownAssessing Noncoding Sequence Variants of GJB2 for Hearing Loss Association.
Not available
S-EPMC3335567 | biostudies-literature
MetabolomicsJ-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis
1H nuclear magnetic resonance (NMR) spectroscopy-based metabolic phenotyping is now widely used for large-scale epidemiological applications. To minimize signal overlap present in 1D 1H NMR spectra, we have investigated the use of 2D J-resolved (JRES) 1H NMR spectroscopy for large-scale phenotyping ...
2018-07-23 | MTBLS540 | MetaboLights
TranscriptomicsPartial de-repression of the hyphal program does not restore hyphae formation in absence of a functional Arp2/3 complex
Deleting components of the Arp2/3 complex in Candida albicans resulted in a global lack of hyphal specific gene induction. This observation suggests that the failure in hyphal growth of Arp2/3 complex mutants could be a result of failure to activate hyphal specific genes. If the hyphal defect was pr...
ORGANISM(S): Candida albicans 
2010-01-22 | E-GEOD-19582 | biostudies-arrayexpress
TranscriptomicsFollicular lymphoma in situ and partial involvement by follicular lymphoma are clona lesions that carry the t(14;18) and lack genetic secondary alterations
Follicular lymphoma (FL) is characterized by the t(14;18)(q32;q21), frequent numerical chromosomal alterations, and recurrent somatic mutations. However, no genetic studies are available for FL in situ (FLIS), a putative precursor lesion of FL. In this study, we analyzed cases of FLIS without manife...
ORGANISM(S): Homo sapiens 
2013-11-12 | E-GEOD-48548 | biostudies-arrayexpress
ProteomicsThe proteomic landscape of CTNNB1 mutated low-grade early-stage endometrial carcinomas
Endometrial carcinoma is the most frequent gynecologic malignancy in western countries. In recent years, mutations in CTNNB1 have been associated with worse prognosis in low-risk carcinomas. However, there is a lack of understanding of the proteomic implications of CTNNB1 mutations in this type of t...
ORGANISM(S): Homo sapiens (Human) 
2025-11-24 | PXD068004 | Pride
Proteomics  endometrial carcinoma  wnt pathway  immune microenvironment 
TranscriptomicsRestoration of miR-214 expression reduces cell growth of myeloma cells through a positive regulation of P53 and inhibition of DNA replication
MicroRNAs have been demonstrated to be deregulated in multiple myeloma (MM). We have previously reported the downregulation of miR-214 in MM compared to normal plasma cells. In the present study, we have explored the functional role of miR-214 in myeloma pathogenesis. Ectopic expression of miR-214 r...
ORGANISM(S): Homo sapiens 
2012-12-28 | E-GEOD-35948 | biostudies-arrayexpress
UnknownThe association between the tumor immune microenvironments and clinical outcome in low-grade, early-stage endometrial cancer patients.
Not available
S-EPMC9828119 | biostudies-literature
TranscriptomicsSingle cell sequencing analysis of senescence in Mus musculus prostate cancer models
Acute Pten loss initiates prostate tumorigenesis characterized by cellular senescence response. Here we examine the cellular senescence response in epithelial individual cells, by single-cell RNA sequencing (scRNAseq) in Ptenpc-/- and Ptenpc-/-; Timp1-/- GEMMs. ScRNAseq analysis determines a cluste...
ORGANISM(S): Mus musculus 
2020-10-09 | E-MTAB-9578 | biostudies-arrayexpress
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
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