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MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
UnknownMemory T Cell Subpopulations as Early Predictors of Remission to Vedolizumab in Ulcerative Colitis.

Background

Vedolizumab is a humanized monoclonal antibody targeting the α4β7 integrin used for the treatment of ulcerative colitis. Few biomarkers related to vedolizumab response have been identified. The aim of this work was to assess whether baseline circulating CD4
S-EPMC9240758 | biostudies-literature
UnknownDurable antibody response one year after hospitalization for COVID-19: A longitudinal cohort study.

Objectives

Durability of the humoral immune response to SARS-CoV-2 has yet to be defined. We longitudinally evaluated during a 12-month period the antibody responses to SARS-CoV-2, and analysed predictors of antibody titres decline and seroreversion.

Methods

Prospective study conducte...
S-EPMC8289631 | biostudies-literature
UnknownMultilayer metabolomic integration reveals bioenergetic disruption in Long COVID.
Not available
S-EPMC12903254 | biostudies-literature
UnknownGOECP/SEOR radiotheraphy guidelines for non-small-cell lung cancer.
Non-small cell lung cancer (NSCLC) is a heterogeneous disease accounting for approximately 85% of all lung cancers. Only 17% of patients are diagnosed at an early stage. Treatment is multidisciplinary and radiotherapy plays a key role in all stages of the disease. More than 50% of patients with NSCL...
S-EPMC9052073 | biostudies-literature
UnknownTLR4-Binding DNA Aptamers Show a Protective Effect against Acute Stroke in Animal Models.
Since Toll-like receptor 4 (TLR4) mediates brain damage after stroke, development of TLR4 antagonists is a promising therapeutic strategy for this disease. Our aim was to generate TLR4-blocking DNA aptamers to be used for stroke treatment. From a random oligonucleotide pool, we identified two aptame...
S-EPMC6094477 | biostudies-literature
UnknownStreamlining Bacillus Strain Selection Against Listeria monocytogenes Using a Fluorescence-Based Infection Assay Integrated into a Multi-Tiered Validation Pipeline
Not available
S-EPMC12383055 | biostudies-literature
UnknownBronchial Aspirate-Based Profiling Identifies MicroRNA Signatures Associated With COVID-19 and Fatal Disease in Critically Ill Patients.

Background

The pathophysiology of COVID-19-related critical illness is not completely understood. Here, we analyzed the microRNA (miRNA) profile of bronchial aspirate (BAS) samples from COVID-19 and non-COVID-19 patients admitted to the ICU to identify prognostic biomarkers of fatal outcomes...
S-EPMC8850692 | biostudies-literature
UnknownN-antigenemia detection by a rapid lateral flow test predicts 90-day mortality in COVID-19: A prospective cohort study.

Objectives

To evaluate if the detection of N antigen of SARS-CoV-2 in plasma by a rapid lateral flow test predicts 90-day mortality in COVID-19 patients hospitalized at the wards.

Methods

The presence of N-antigenemia was evaluated in the first 36 hours after hospitalization in 600 un...
S-EPMC9150910 | biostudies-literature
UnknownIdentification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS.
There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS. The study i...
S-EPMC9176679 | biostudies-literature
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