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TranscriptomicsThe NS1 protein of influenza A virus suppresses interferon-regulated activation of antigen-presentation and immune-proteasome pathways
The NS1 protein of influenza virus counters host antiviral defences primarily by antagonizing the type I interferon (IFN) response. Both the N-terminal dsRNA-binding domain and the C-terminal effector domain are required for optimal suppression of host responses during infection. To better understan...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-GEOD-39200 | biostudies-arrayexpress
UnknownVirus induced autophagic degradation of STAT2 as a mechanism for interferon signaling blockade
Not available
S-SCDT-EMBOR-2019-48766-T | biostudies-other
GenomicsSARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
PRJNA669833 | ENA
TranscriptomicsAcute host transcriptonal response to A/Texas/36/91 influenza and A/Texas/36/91 influenza containing the NS1 gene from r1918 in A549 cells
The M-bM-^@M-^\Spanish influenzaM-bM-^@M-^] of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transc...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-37829 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis Rhinolophus ferrumequinum (Rfe) cells upon poly-I:C transfection
Transcriptome analysis Rhinolophus ferrumequinum (Rfe) cells upon poly-I:C transfection. Rfe cell expressing human ACE2 and TMPRSS2 (Rfe-AT) and a SARS-Cov-2 / BANAL-236 successible clonal Rfe-AT cell line (Rfe-ATC) were transfected with poly-I:C or PBS and transcriptome was analysed using RNA seque...
ORGANISM(S): Rhinolophus ferrumequinum 
2026-04-10 | E-MTAB-16878 | biostudies-arrayexpress
ProteomicsFluOMICS - Metabolomics analysis of mouse lungs infected with H1N1 influenza virus
Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/California/04/09 (H1N1) virus, mock infected with PBS, or untreated.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-12-06 | MSV000081785 | MassIVE
TranscriptomicsAcute host transcriptonal response to r1918 influenza and r1918 influenza containing the NS1 gene from A/Texas/36/91 in A549 cells
The “Spanish influenza” of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transcriptional response t...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-37951 | biostudies-arrayexpress
MetabolomicsGNPS - FluOMICS - Metabolomics analysis of mouse lungs infected with H1N1 influenza virus
Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/California/04/09 (H1N1) virus, mock infected with PBS, or untreated.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-12-06 | MSV000081785 | GNPS
MetabolomicsGNPS - FluOMICS - Metabolomics analysis of mouse lungs infected with H5N1 (HALo) influenza virus
Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/Vietnam/1203/04 (H5N1) HALo virus, mock infected with PBS, or untreated.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-12-06 | MSV000081786 | GNPS
ProteomicsFluOMICS - Metabolomics analysis of mouse lungs infected with H5N1 (HALo) influenza virus
Metabolomics analysis of C57BL/6 mouse lungs infected with influenza A/Vietnam/1203/04 (H5N1) HALo virus, mock infected with PBS, or untreated.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-12-06 | MSV000081786 | MassIVE
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