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GenomicsGenome-wide DNA methylation profiling reveals epigenetic changes in the rat nucleus accumbens associated with cross-generational effects of adolescent THC exposure
Drug exposure during critical periods of development is known to have lasting effects, increasing one’s risk for developing mental health disorders. Emerging evidence has also indicated the possibility for drug exposure to even impact subsequent generations. Our previous work demonstrated that adole...
ORGANISM(S): Rattus norvegicus 
2015-06-19 | E-GEOD-69984 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of uniparental disomy cases reveals many novel imprinted loci in the human genome.
Genomic imprinting is a mechanism in which the expression of genes varies depending on their parent-of-origin. Imprinting occurs through differential DNA methylation and histone modifications on the two parental alleles, with most imprinted genes marked by CpG-rich differentially methylated regions ...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-64244 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease
Recent work has identified roles for environmental, genetic and epigenetic factors in AD risk. Motivated by suspected roles for epigenetic modifications in AD, we performed a genome-wide screen of DNA methylation using the Illumina Infinium HumanMethylation450 array platform on bulk tissue samples f...
ORGANISM(S): Homo sapiens 
2015-12-18 | E-GEOD-76105 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling in X;autosome translocations supports a role for L1 repeats in the spread of X chromosome inactivation
In order to test the hypothesis that X chromosome inactivation shows sequence specificity, we have analysed the spread of XCI into autosomal chromatin by performing DNA methylation profiling in six unbalanced X;autosome translocations. Using promoter hypermethylation as an epigenetic signature of XC...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-50837 | biostudies-arrayexpress
TranscriptomicsA genome-wide comparative study of DNA methylation in great apes
DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex diseases. These changes can be inherited through generations and likely have played an important...
ORGANISM(S): Gorilla gorilla gorilla 
2013-06-01 | E-GEOD-41782 | biostudies-arrayexpress
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