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TranscriptomicsTranscription profiling of murine macrophage-like RAW 264.7 cells treated with EdTx, protective antigen, or LPS for different length of time to examine the effect of EdTx on global transcriptional profiles.
Edema toxin (EdTx), which is a combination of edema factor and a binding moiety (protective antigen), is produced by Bacillus anthracis, the etiological agent of anthrax. EdTx is an adenylyl cyclase enzyme that converts adenosine triphosphate to adenosine-3',5'-monophosphate, resulting in interstiti...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4712 | biostudies-arrayexpress
TranscriptomicsBrucella melitensis global gene expression
In this study we report that B. melitensis at the late logarithmic phase of growth are more invasive for HeLa cells than at mid logarithmic or stationary growth phases. Microarray analysis of B. melitensis gene expression identified 414 up- and 40 down-regulated genes in late-log growth phase compar...
ORGANISM(S): Brucella melitensis 
2010-05-19 | E-GEOD-11192 | biostudies-arrayexpress
TranscriptomicsRole of SPI-1 Secreted Effectors, SipA, SopABDE2, in Acute Bovine Response to Salmonella enterica Serovar Typhimurium
Salmonella enterica Serovar Typhimurium (S. Typhimurium) causes enterocolitis in humans and calves characterized by diarrhea and polymorphonuclear cell (PMN) influx to the intestinal mucosa. The Salmonella Type III Secretion System encoded at Pathogenicity Island I (SPI-1) translocates the Salmonel...
ORGANISM(S): Bos taurus 
2012-01-10 | E-GEOD-13847 | biostudies-arrayexpress
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