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TranscriptomicsTranscription profiling of murine GATA-1 wild type and mutant fetal megakaryocytes to understand the molecular basis for the megakaryocytic hyperproliferation phenotype of the GATA-1deltaN mutants
Background: Children with Down syndrome (DS) are predisposed to acute megakaryoblastic leukemia (AMKL, or AML M7) and a related myeloid disorder, referred to as transient myeloproliferative disorder (TMD), or transient leukemia (TL). Recently, acquired mutations in the erythroid/megakaryocytic linea...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2433 | biostudies-arrayexpress
Transcriptomicsrec-Y2H matrix in S. cerevisiae screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins
RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, sequence motifs recognized by RBPs are typically a poor predictor of RBP-RNA in...
ORGANISM(S): Saccharomyces cerevisiae 
2021-09-01 | E-MTAB-9612 | biostudies-arrayexpress
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