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TranscriptomicsIntegrated microRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) includes basal and non-basal subclasses. To further stratify TNBC we determined microRNA (miRNA) and mRNA expression profiles, linked specific miRNA signatures to patient survival and used miRNA/mRNA anti-correlations to identify TNBC subclasses associated with e...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-41970 | biostudies-arrayexpress
TranscriptomicsTWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis
Using a TWIST1-inducible epithelial-to-mesenchymal transition (EMT) model in HMLE cells, miRNA changes were profiled at different time points during an active EMT. This experiment includes a total of 12 samples consisting of 2 experimental groups at 2 matching time points (day 4, day 12), each with ...
ORGANISM(S): Homo sapiens 
2015-02-26 | E-GEOD-58560 | biostudies-arrayexpress
TranscriptomicsTWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis
Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity; an EMT/MET axis is critical for metastatic colonization of carcinomas. Unlike epithelial programming, regulation of mesenchymal programming is not well understood in EMT. Here we describe the first mi...
ORGANISM(S): Homo sapiens 
2015-02-26 | E-GEOD-54505 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human breast cancer cell lines with different ERalpha status
In order to identify the microRNAs differentially expressed according to the estrogen receptor status, total RNAs in triplicate from six breast cancer cell lines with different ERalpha status (ER+: T47D, BT-474, MDA-MB-483; ER-: MDA-MD-436, MDA-MB-231, MDA-MB-468) was extracted by using Trizol reag...
ORGANISM(S): Homo sapiens 
2009-12-11 | E-TABM-596 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [Affymetrix]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-41972 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [NanoString]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2012-11-02 | E-GEOD-41971 | biostudies-arrayexpress
TranscriptomicsIn vivo NCL-targeting affects breast cancer aggressiveness through miRNA regulation [RNA-seq]
Numerous studies have described the altered expression and the causal role of miRNAs in human cancer. However, to date efforts to modulate miRNA levels for therapeutic purposes have been challenging to implement. Here, we find that Nucleolin (NCL), a major nucleolar protein, post-transcriptionally r...
ORGANISM(S): Homo sapiens 
2013-02-07 | E-GEOD-44052 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human acute myeloid leukemia samples
AML
ORGANISM(S): Homo sapiens 
2010-05-10 | E-TABM-972 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human ovarian carcinoma samples
OVARIAN EPITHELIAL CARCINOMA
ORGANISM(S): Homo sapiens 
2010-05-10 | E-TABM-975 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human chronic lymphocytic leukemia samples
CLL
ORGANISM(S): Homo sapiens 
2010-05-10 | E-TABM-973 | biostudies-arrayexpress
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