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TranscriptomicsEsophageal epithelium of 12 weeks old mice (WT, Nrf2-/-) on C57BL background with or without gastroesophageal reflux for 4 weeks.
Transcriptional profiling of adult esophageal epithelium comparing wild-type mice with Nrf2-/- mice with or without gastroesophageal reflux for 4 weeks. Goal was to determine the role of Nrf2 on the barrier function of mouse esophageal epithelium. Two-class comparisons. Wild-type/without reflux vs. ...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-39629 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics profiling of esophageal tissues from a rat model of reflux esophagitis treated with Shunwei Jiangni Decoction

This dataset contains raw untargeted metabolomics data generated from esophageal tissue samples of rats in a reflux esophagitis (RE) model. The study aimed to characterize metabolic alterations associated with RE pathogenesis and to evaluate the regulatory effects of Shunwei Jiangni Decoction (SW...

2026-04-10 | MTBLS14112 | MetaboLights
MetabolomicsMechanisms of action of bile acids in pediatric gastroesophageal reflux: Exploration through non-targeted and targeted metabolomics methods

Purpose: To investigate the pathogenesis of pediatric bile reflux gastritis (BRG) using non-targeted and targeted metabolomics analyses of the changes and content differences of bile acids (BAs) in gastric juice. Methods: Data from 25 pediatric BRG patients treat...

2025-12-05 | MTBLS13459 | MetaboLights
MetabolomicsMechanisms of action of bile acids in pediatric gastroesophageal reflux: Exploration through non-targeted and targeted metabolomics methods

Purpose: To investigate the pathogenesis of pediatric bile reflux gastritis (BRG) using non-targeted and targeted metabolomics analyses of the changes and content differences of bile acids (BAs) in gastric juice. Methods: Data from 25 pediatric BRG patients treated at Jinhua Maternal and Child He...

2025-12-04 | MTBLS13450 | MetaboLights
MetabolomicsMulti-omics analysis identifies gut microbiota-glutamine axis contributing to the pathogenesis of reflux esophagitis

Background: Reflux esophagitis (RE), a common gastroesophageal reflux disease characterized by esophageal mucosal inflammation, is closely associated with gut microbiota dysbiosis and metabolic abnormalities. The glutamine-glutamate metabolic pathway regulates inflammation and mucosal barrier fun...

2026-05-03 | MTBLS14421 | MetaboLights
TranscriptomicsBeyond acid suppression: Novel therapeutic targets for gastro-esophageal reflux disease based on a murine model (esophageal tissue)
Background & Aims: Because the pathophysiology of GERD is not fully understood, presently used drug target only one or more of the known underlying mechanisms but are not fully effective in all patients. 1Identifying novel central targets may pave the way to develop more effective agents. Methods: A...
ORGANISM(S): Rattus norvegicus 
2015-12-16 | E-GEOD-63401 | biostudies-arrayexpress
TranscriptomicsBeyond acid suppression: Novel therapeutic targets for gastro-esophageal reflux disease based on a murine model (whole blood)
Background & Aims: Because the pathophysiology of GERD is not fully understood, presently used drug target only one or more of the known underlying mechanisms but are not fully effective in all patients. 1Identifying novel central targets may pave the way to develop more effective agents. Methods: A...
ORGANISM(S): Rattus norvegicus 
2015-12-16 | E-GEOD-63402 | biostudies-arrayexpress
TranscriptomicsBeyond acid suppression: Novel therapeutic targets for gastro-esophageal reflux disease based on a murine model
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2015-12-16 | E-GEOD-63403 | biostudies-arrayexpress
GenomicsCharacterisation of the sensory phenotype of the oesophageal mucosa in gastroesophageal reflux disease
Characterisation of the sensory phenotype of the oesophageal mucosa in gastroesophageal reflux disease
PRJNA939567 | ENA
ProteomicsDynamics of Germinosome Formation Interactions between GerD and Germinant Receptor Subunits in Bacillus cereus Spores
Spores of the bacterium Bacillus cereus can cause disease in humans due to contamination of raw materials for food manufacturing. These dormant, resistant spores can survive for years in the environment, but can germinate and grow when their surroundings become suitable, and spore germination protei...
ORGANISM(S): Bacillus Cereus (ncbitaxon:1396) 
2022-01-24 | MSV000088726 | MassIVE
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