Sort   by:  
 Page size 
ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoid
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to22 batch variation, high cost, a...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-01-31 | PXD023705 | Pride
Gastrointestinal organoid Tissue extracellular matrix 
TranscriptomicsBulk RNA-seq of MilliporeSigma 3DGro human patient-derived gastrointestinal organoid lines compared to SCC300 human iPSC-derived colon organoid line
Transcriptomic profiles of 6 commercially-available human patient-derived gastrointestinal organoid lines were obtained and compared to transcriptomic profile of a commercially available human iPSC-induced colon organoid line. Transcriptomic profile of iPSC-derived human colon organoid line was comp...
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-11557 | biostudies-arrayexpress
TranscriptomicsAnalysis of human enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent 5-fluorouracil (5FU) in a dose-repeated exposure across three doses (10,100 and 1000uM) and sampled at three points (24, 48 and 72h) since initial exposure. Organoids were obtained from healthy human tissues.
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-9134 | biostudies-arrayexpress
UnknownPatient-Derived Organoid Facilitating Personalized Medicine in Gastrointestinal Stromal Tumor With Liver Metastasis: A Case Report.
Not available
S-EPMC9378866 | biostudies-literature
TranscriptomicsRNA-seq of human epithelium-only colonic and small intestinal organoids derived from intestinal resections, biopsy specimens and cryopreserved crypts
Patient-derived gastrointestinal epithelium-only organoids from the small and large intestine, also referred to as colonoids and enteroids, were generated as part of the development of an on-going organoid biobank at the Michigan Medicine Translational Tissue Modeling Laboratory (TTML) (www.UmichTTM...
ORGANISM(S): Homo sapiens 
2020-07-24 | E-MTAB-9339 | biostudies-arrayexpress
TranscriptomicsAnalysis of human enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent and tyrosine kinase inhibitor (TKI) gefitinib sampled at four doses (0.1, 1, 10 and 30uM) and at three time points (24, 48 and 72h) since initial exposure
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2022-04-11 | E-MTAB-11221 | biostudies-arrayexpress
TranscriptomicsAnalysis of human healthy enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent Doxorubicin (DOX) sampled at four doses (1,10, 30 and 60uM) and three time points (24, 48 and 72h).
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11297 | biostudies-arrayexpress
ProteomicsSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection of Jamaican Fruit Bat Intestinal Epithelial Cells Induces Robust Interferon Activation
Bats are the most important natural reservoirs for a variety of emerging viruses that cause several illnesses in humans and other mammals. Increased viral shedding by bats is thought to be linked to an increased ability of many bat species to tolerate viral infection. The severe acute respiratory sy...
ORGANISM(S): Artibeus jamaicensis 
2024-01-26 | PXD036016 | Pride
Sars-cov-2 Dia Interferon Jamaican fruit bats 
GenomicsBulk RNA-seq of MilliporeSigma 3DGro human patient-derived gastrointestinal organoid lines compared to SCC300 human iPSC-derived colon organoid line
Bulk RNA-seq of MilliporeSigma 3DGro human patient-derived gastrointestinal organoid lines compared to SCC300 human iPSC-derived colon organoid line
PRJEB51823 | ENA
ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoids
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to batch variation, high cost, and...
ORGANISM(S): Sus scrofa (Pig) Mus musculus (Mouse) 
2022-02-10 | PXD023694 | Pride
Organoid Matrigel Lc-ms/ms 
Sort   by:  
 Page size