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TranscriptomicsArray CGH analysis of human gastrointestinal stromal tumors
Gastrointestinal stromal tumors (GISTs) are the most important mesenchymal tumors of the gastrointestinal tract. The vast majority of GISTs exhibit activating mutations of KIT or PDGFRA, but epigenetic alteration of GISTs is largely unknown. In this study, we aimed to clarify the involvement of DN...
ORGANISM(S): Homo sapiens 
2010-06-20 | E-GEOD-22185 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human gastrointestinal stromal tumour is predictive of rapid response to imatinib mesylate
Gene expression profiling using oligonucleotide microarrays performed on tumor samples obtained before and after imatinib mesylate (IM) therapy. Rapid responding (to IM) samples were compared to non-responding/stable disease samples as measured by CT scan measurements to identify a gene signature t...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-15966 | biostudies-arrayexpress
TranscriptomicsOncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor
We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those beari...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-34387 | biostudies-arrayexpress
TranscriptomicsGastrointestinal stromal tumor GIST: gene expresssion and ChIP analyses
This SuperSeries is composed of the following subset Series: GSE19396: ETV1 knockdown in GIST cell lines GSE22433: Imatinib Treatment of GIST882 GSE22441: Mapping of ETV1 genomic binding sites in gastrointestinal stromal tumor (GIST). Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-10-14 | E-GEOD-22852 | biostudies-arrayexpress
TranscriptomicsCopy number data from GIST with KIT mutation
In addition to KIT and PDGFRA mutations, sequential accumulation of other genetic events is involved in the development and progression of gastrointestinal stromal tumors (GISTs). Until recently, the significance of these other alterations has not been thoroughly investigated. The combination of gen...
ORGANISM(S): Homo sapiens 
2010-08-27 | E-GEOD-20709 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human leiomyosarcomas and gastrointestinal stromal tumors
Profiling of DNA copy number changes in human Leiomyosarcomas and Gastrointestinal Stromal Tumors using array CGH
ORGANISM(S): Homo sapiens 
2006-09-20 | E-MEXP-707 | biostudies-arrayexpress
ProteomicsCombined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor
AKT activation is a hallmark of IM resistance in GIST. The presence of an additional therapeutic agent could potentially suppress the growth and survival of a clone of cancer cells, which have developed resistance to IM. Simultaneous targeting of AKT in addition to inhibiting KIT with IM has potenti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-20 | MSV000086739 | MassIVE
UnknownComparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: a meta-analysis of 1,640 patients.
Not available
S-EPMC2834472 | biostudies-literature
TranscriptomicsTranscription profiling of human gastrointestinal stromal tumor (GIST) reveals gene expression determined distinct classes.
GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GIST is poorly understood. We analysed the expression levels of 54,613 probe sets in 32 surgical samples of untr...
ORGANISM(S): Homo sapiens 
2008-10-18 | E-GEOD-8167 | biostudies-arrayexpress
ProteomicsKinome Profiling of Gastrointestinal Stromal Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies Wee1 as a Candidate Therapeutic Target
Purpose: Management of gastrointestinal stromal tumor (GIST) has been revolutionized by the identification of activating mutations in KIT and PDGFRA and the clinical application of receptor tyrosine kinase (RTK) inhibitors in the advanced disease setting. Stratification of GIST into molecularly defi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020720 | Pride
Gastrointestinal stromal tumor Pdgfra Kit 
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