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TranscriptomicsComparison of gene expression alterations induced by distinct PI3K inhibitors
The goal is the characterization of the off-target activity of BKM120 observed in A2058 human melanoma cell line at IC90 concentration (3.606 µM) but not at lower concentrations. Controls are BEZ235, GDC0941, showing no off-target activity. A secondary objective is the characterizations of drug eff...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-33643 | biostudies-arrayexpress
GenomicsChIP-seq for PAX8 and histone modifications in Renal Cell Carcinoma cell lines.
In this experiment we analyzed the genome wide occupancy of PAX8 by ChIP-seq in four Renal Cell Carcinoma cell lines. Additionally we performed ChIP-seq also for histone modifications correlated with transcriptional activity (H3K27ac), enhancers (H3K4me1) and promoters (H3K4me3). Unrelated IgG was u...
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7812 | biostudies-arrayexpress
TranscriptomicsATAC-seq in Renal Cell Carcinoma cell lines
In this experiment we profiled the genome wide chromatin accessibility in 4 Renal Cell Carcinoma cell lines.
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7844 | biostudies-arrayexpress
TranscriptomicsRNA-seq upon PAX8 knockdown in Renal Cell Carcinoma cell lines
In this experiment we examined the genes regulated by PAX8 knockdown in four renal cell carcinoma models. Four different cell lines bearing a validated doxycycline (DOX) inducible shRNA against PAX8 were treated with DOX for 96 hours and their gene expression profile analyzed by RNA-seq.
ORGANISM(S): Homo sapiens 
2019-06-28 | E-MTAB-7808 | biostudies-arrayexpress
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