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TranscriptomicsBiological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen® cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up t...
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10166 | biostudies-arrayexpress
TranscriptomicsA 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysema following smoking cessation or switching to e-vapor products.
Cigarette smoking causes serious diseases, including lung cancer, heart disease, and emphysema. While cessation remains the most effective approach to minimize smoking-related disease, alternative non-combustible tobacco-derived nicotine containing products may reduce disease risks among those unabl...
ORGANISM(S): Mus musculus 
2021-03-18 | E-MTAB-9597 | biostudies-arrayexpress
TranscriptomicsAortic macrophages and endothelial cells of apoE KO mice aortas after plaque regression induced apoE adenoviral transfer
Aortic macrophages and endothelial cells of apoE KO mice were sorted and analyzed by microarray 2 weeks after regression was induced by adenoviral transfer of apoE. Aortic macrophages (CD45+ F4/80+ CD11b+) and endothelial cells (CD45- CD31+) were sorted from apoE KO mice and the RNA extracted and hy...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-42691 | biostudies-arrayexpress
ModelsVerlingue2016 - Signalling pathway that control S-phase entry and geroconversion - Boolean Model
Verlingue2016 - Signalling pathway that control S-phase entry and geroconversion - Boolean Model This model is described in the article: A comprehensive approach to the molecular determinants of lifespan using a Boolean model of geroconversion. Verlingue L, Dugourd A, Stoll G,...
2016-11-29 | MODEL1611180000 | BioModels
TranscriptomicsStructural, Functional and Molecular Impact on the Cardiovascular System in ApoE-/- Mice Exposed to Aerosol from modified risk tobacco products, the Carbon Heated Tobacco Product 1.2 and the Tobacco Heating System 2.2 compared to Cigarette Smoke effects (mRNA data).
AIM: To investigate the molecular, structural, and functional impact of aerosols from two heat-not-burn-based MRTPs, the Carbon Heated Tobacco Product (CHTP) 1.2 and Tobacco Heating System (THS) 2.2, compared with that of cigarette mainstream smoke (CS) on the cardiovascular system of ApoE-/- mice. ...
ORGANISM(S): Mus musculus 
2021-08-16 | E-MTAB-7980 | biostudies-arrayexpress
TranscriptomicsAnatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis.
Objective: In this study, we aimed to evaluate the anti-inflammatory properties of nicotine and anatabine in a dextran sulfate sodium (DSS) mouse model of ulcerative colitis (UC). Methods: C57BL/6 male mice (10 groups with 8 animals each) were orally administered nicotine at a concentration of 5 or ...
ORGANISM(S): Mus musculus 
2020-11-03 | E-MTAB-8543 | biostudies-arrayexpress
TranscriptomicsThe reduction of dextran sulfate sodium-induced colitis severity in mice exposed to cigarette smoke is accompanied by specific gene pathway and microbial shifts.
Background and Aims: The impact of cigarette smoke on inflammatory bowel disease has been established by a large number of epidemiological, clinical, and preclinical studies. Exposure to cigarette smoke is associated with a higher risk of developing Crohn’s disease but is inversely correlated with t...
ORGANISM(S): Mus musculus 
2020-03-03 | E-MTAB-7988 | biostudies-arrayexpress
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