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MetabolomicsMetabolomic Changes in Idiopathic and GBA1 Parkinson’s Disease

Background Variants in the β-glucocerebrosidase (GBA1) gene are the commonest genetic risk factor for Parkinson Disease (PD). Here, we use mass spectrometry based metabolomics to analyse serum and sebum samples from 50 genotyped participants and find differences in lipid and sugar reg...

2025-09-18 | MTBLS10743 | MetaboLights
GenomicsStreptomyces sp. GBA 94
Streptomyces sp. GBA 94-10 4N24 Genome sequencing and assembly
PRJNA891639 | ENA
MetabolomicsSex differences modulate the serum metabolome profiles in Parkinson’s disease patients harbouring pathogenic mutations in GBA1, LRRK2, TMEM175, PARK2, PINK1, and PARK7 genes

Background: Sex and genetic background have an impact on Parkinson’s disease (PD) insurgence, but the comprehension of how these factors affect the circulating profile of PD patients is still an aim of study.

Objectives: In this study we aimed to investigate whether genetic background and ...

2026-06-26 | MTBLS12753 | MetaboLights
ProteomicsProteomic analysis of GBA iPSC-dopamine neurons
Heterozygous mutations in the glucocerebrosidase gene (GBA) are the strongest common genetic risk factors for Parkinson’s disease (PD) present in around 5-10% of PD patients, resulting in lower age of onset and exacerbating disease progression, including an increased risk of dementia. However, the e...
ORGANISM(S): Homo sapiens (Human) 
2023-03-04 | PXD026691 | Pride
Neuritogenesis/parkinson’s/proteomics/stem cells/glucocerebrosidase/post-translational modification 
GenomicsGBA coastal samples
GBA coastal samples Raw sequence reads
PRJNA717892 | ENA
GenomicsComparative transcriptome analysis in monocyte-derived macrophages of asymptomatic GBA mutation carriers and patients with GBA-associated Parkinson’s disease
Comparative transcriptome analysis in monocyte-derived macrophages of asymptomatic GBA mutation carriers and patients with GBA-associated Parkinson’s disease
PRJNA767096 | ENA
GenomicsComparative transcriptome analysis in monocyte-derived macrophages of asymptomatic GBA mutation carriers and patients with GBA-associated Parkinson’s disease
Comparative transcriptome analysis in monocyte-derived macrophages of asymptomatic GBA mutation carriers and patients with GBA-associated Parkinson’s disease
PRJEB47982 | ENA
GenomicsStreptomyces sp. GBA 94-10 4N24
Streptomyces sp. GBA 94-10 4N24 Genome sequencing
PRJNA171847 | ENA
TranscriptomicsComparative transcriptome analysis in monocyte-derived macrophages of asymptomatic GBA mutation carriers and patients with GBA-associated Parkinson’s disease
We compared transcriptome of monocyte-derived macrophages of 5 patients with GBA-PD (4 L444P/N, 1 N370S/N) and 4 asymptomatic GBA mutation carriers (GBA-carriers) (3 L444P/N, 1 N370S/N) and 4 controls. We also conducted comparative transcriptome analysis for L444P/N only GBA-PD patients and GBA-carr...
ORGANISM(S): Homo sapiens 
2021-10-12 | E-MTAB-11029 | biostudies-arrayexpress
GenomicsGene expression of microglia from wild type, Gba flox/flox Nestin-Cre, and Gba flox/flox Nestin-Cre Mincle-/- mice
Gene expression of microglia from wild type, Gba flox/flox Nestin-Cre, and Gba flox/flox Nestin-Cre Mincle-/- mice
PRJNA842510 | ENA
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