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TranscriptomicsMeta-transcriptomic analysis of the response of river biofilms to pharmaceutical products using anonymous DNA microarray
Low concentrations of pharmaceutical compounds were shown to induce transcriptional responses in isolated microorganisms, which could have consequences on ecosystem dynamics. In order to test if these transcriptional responses could also be observed in complex river microbial communities, biofilm re...
ORGANISM(S): environmental samples 
2010-07-06 | E-GEOD-20501 | biostudies-arrayexpress
TranscriptomicsMicroarray expression profiling of mRNAs in the developing murine first molar tooth ge
The global gene expression of murine tooth germs dissected at various stages of tooth development was investigated. A list of genes differentialy expressed throughout the various time points was submitted to bioinformatic analysis using Ingenuity Pathway Analysis (IPA) to identify significant assoc...
ORGANISM(S): Mus musculus 
2012-11-14 | E-MEXP-3581 | biostudies-arrayexpress
TranscriptomicsMicroarray correpsonding to the paper manuscript titled: Targeted expression profiling of single disseminated cancer cells isolated from bone marrow of prostate cancer patients
Bone is the most frequent site of metastasis in prostate cancer (PCa) and patients with bone metastases are deemed incurable. Targeting prostate cancer cells that disseminated to the bone marrow (BM) prior to surgery and before metastatic outgrowth may therefore prevent lethal metastasis. This promp...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-59631 | biostudies-arrayexpress
TranscriptomicsA microarray approach to identify genes involved in seed and mesocarp development in peach
Background Field observations and a few physiological studies pointed out that peach embryogenesis and fruit development are strictly related. In fact, attempts to stimulate parthenocarpic fruit development by means of external tools failed. Moreover, physiological disturbances during the early embr...
ORGANISM(S): Prunus persica 
2011-06-27 | E-GEOD-22582 | biostudies-arrayexpress
TranscriptomicsThermotoga species transcription on glucose and a mix of polysaccharides
Hyperthermophilic bacteria of the genus Thermotoga are known to utilize a wide range of simple and complex polysaccharides. T. maritima's transcriptional response to a variety of mono- and poly-saccharides was previously studied to assign functions to genes involved in carbohydrate uptake and utiliz...
ORGANISM(S): Thermotoga petrophila 
2012-01-05 | E-GEOD-29557 | biostudies-arrayexpress
TranscriptomicsGene expression profile of a S. cerevisiae strain deleted in CSN5/RRI1 gene (systematic name YDL216C)
The COP9 signalosome (CSN) is a highly conserved eukaryotic protein complex which regulates the Cullin-RING family of ubiquitin ligases and carries out a deneddylase activity that resides in subunit 5 (CSN5). The budding yeast CSN is biochemically active and deletion mutants of each of its subunits ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-23 | E-GEOD-51563 | biostudies-arrayexpress
ProteomicsA chemical probe for Tudor domain protein SPIN1 to investigate chromatin functions
Lysine and arginine methylation are amongst the most frequent modifications on unstructured histone tails and in combination with other modifications provide the basis for a combinatorial 'chromatin or histone code'. Recognition of modified histone residues is accomplished in a specific manner by 'r...
ORGANISM(S): Homo sapiens (Human) 
2022-02-23 | PXD011703 | Pride
Affinity enrichment Chemical probe 
TranscriptomicsTranscriptional profile of Beijing/East-Asian Mycobacterium tuberculosis isolates
Transcriptional profile comparison among Beijing and non-Beijing M. tuberculosis isolates. Three M. tuberculosis strains were compared. The laboratory reference strain, H37Rv, belongs to the Euro-American or lineage 4. Two clinical isolates of the East-Asian or lineage 2: 98_1663 is a pre-Beijing or...
ORGANISM(S): Mycobacterium tuberculosis 
2016-06-24 | E-GEOD-83677 | biostudies-arrayexpress
TranscriptomicsIL-17A plays a central role in the expression of psoriasis signature genes through induction of IkappaB-zeta in keratinocytes
In psoriasis lesions, a diverse mixture of cytokines is upregulated which influence each other generating a complex inflammatory situation. Although this is the case, the inhibition of Interleukin-17A (IL-17A) alone showed unprecedented clinical results in patients, indicating that IL-17A is a criti...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-77719 | biostudies-arrayexpress
TranscriptomicsGene expression of Bone marrow-derived macrophages isolated in ERR-alpha knock-out mice
We investigated the molecular mechanisms by which ERRM-NM-1 negatively regulates TLR-signaling pathways. To examine this, we performed global gene expression analysis of ERRM-NM-1+/+ and ERRM-NM-1-/- BMDMs after LPS stimulation. Microarray analysis revealed that several genes encoding various TLR-ne...
ORGANISM(S): Mus musculus 
2014-06-17 | E-GEOD-58515 | biostudies-arrayexpress
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