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TranscriptomicsTranscriptional profile comparison of M. tuberculosis PDIM spontaneous mutants
Transcriptional profile comparison among PDIM positive and negative isolates. Standard in vitro exponential phase cultures of M. tuberculosis H37Rv ATCC27294 were plated on 7H11 plates. Individual colonies were sub-cultured in 7H9 broth and metabolically labeled with [14C] propionic acid. The apolar...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-16 | E-GEOD-17234 | biostudies-arrayexpress
TranscriptomicsGenomic comparison of M. tuberculosis PDIM spontaneous mutants
Genomic comparisons among PDIM positive and negative isolates. Standard in vitro exponential phase cultures of M. tuberculosis H37Rv ATCC27294 were plated on 7H11 plates. Individual colonies were sub-cultured in 7H9 broth and metabolically labeled with [14C] propionic acid. The apolar lipid fraction...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-16 | E-GEOD-17232 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in the largemouth bass ovary following sub-chronic dietary exposures to the organochlorine pesticides p,pM-bM-^@M-^Y DDE and methoxychlor
Largemouth bass (Micropterus salmoides) (LMB) inhabiting Lake Apopka, Florida are exposed to high levels of organochlorine pesticides (OCPs) that exert effects through multiple modes of action. The objectives of this study were to assess the impacts of two OCPs (p,p'-Dichlorodiphenyldichloroethylen...
ORGANISM(S): Micropterus salmoides 
2013-08-10 | E-GEOD-47675 | biostudies-arrayexpress
TranscriptomicsThe N-glycosylated isoform of M-NM-2-integrin as a potential biomarker and target in HER-2+ BC refractory to HER-2 targeted therapies.
Acquired resistance to trastuzumab, a rationally designed HER-2 targeting antibody, remains a major hurdle in management of HER-2 positive breast cancer (HER-2+ BC) patients. Potential resistance mechanisms are numerous, derived primarily from studies where HER-2 positive cell lines are chronically...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-40152 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human neuroblastoma cell lines treated with the ATR inhibitor BAY 1895344
To characterize the downstream gene expression response following ATR inhibition, we performed RNA-Seq after treatment of CLB-BAR and CLB-GE neuroblastoma cells with 50 nM of the ATR inhibitor BAY 1895344 for 24h and 48h
ORGANISM(S): Homo sapiens 
2021-10-21 | E-MTAB-10603 | biostudies-arrayexpress
TranscriptomicsMeiotic DNA double strand breaks in the yeast Saccaromyces cerevisiae
DNA double-strand breaks (DSBs) initiate meiotic recombination. Past DSB-mapping studies have used rad50S or sae2? mutants, which are defective in break processing, to accumulate DSBs, and report large (= 50 kb) “DSB-hot” regions that are separated by “DSB-cold” domains of similar size. Substantial ...
ORGANISM(S): Saccharomyces cerevisiae 
2007-12-30 | E-GEOD-8981 | biostudies-arrayexpress
TranscriptomicsExperimental validation of HiSpOD probe design with complex background mRNA or 3 known antiense RNA and expression analysis on a contaminated groundwater sample
HiSpOD is a new efficient functional microarrays probe design algorithm especially dedicated for the microbial ecology and environmental studies. It was used to design 3392 probes targeting 21 genes involved in chlorinated solvent biodegradation pathways and synthesized on a nimblegen microarray. In...
ORGANISM(S): uncultured organism 
2011-04-13 | E-GEOD-21492 | biostudies-arrayexpress
TranscriptomicsSMC5/6 facilitates joint molecule resolution and stepwise loss of cohesin to promote meiotic chromosome segregation
During meiosis, Structural Maintenance of Chromosome (SMC) complexes underpin two fundamental features of meiosis: homologous recombination and chromosome segregation. While meiotic functions of the cohesin and condensin complexes have been delineated, the role of the third SMC complex, Smc5/6, rema...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-27 | E-GEOD-44852 | biostudies-arrayexpress
ProteomicsAppressorial proteomics analysis of the wild-type and GAG biosynthetic mutant of Metarhizium robertsii
Exopolysaccharide galactosaminogalactan (GAG) is a fungal cell wall component composed of α-1,4 linked galactose, N-acetyl galactosamine and galactosamine, which has been demonstrated in Aspergillus fumigatus in association with fungal adhesion, biofilm formation and virulence. The gene cluster resp...
ORGANISM(S): Metarhizium robertsii 
2021-06-07 | PXD019301 | Pride
Itraq Metarhizium robertsii Gag 
TranscriptomicsA comparison between egg trancriptomes of cod and salmon reveals species specific traits in eggs for each species
Fish in use in aquaculture display large variation in gamete biology. To reach better understanding around this issue, this study aims at identifying if M-bM-^@M-^\egg life history traitsM-bM-^@M-^] can be hidden in egg transcriptomes. To pursue this, salmon and cod eggs were selected due to their l...
ORGANISM(S): Salmo salar 
2014-08-31 | E-GEOD-59877 | biostudies-arrayexpress
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