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TranscriptomicsLMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression
The mRNA processing body is a cellular structure that regulates the stability of cytoplasmic mRNA. MARF1/LMKB is an RNA-binding protein that is associated with maintenance of mRNA homeostasis and genomic stability. To investigate the function of LMKB in a human B lymphocyte cell line, BJAB cells w...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-55974 | biostudies-arrayexpress
TranscriptomicsGenome-wide location analysis of Dnmt3a-mediated epigenetic regulation in murine postnatal subventricular zone (SVZ) neural stem cells (NSCs) [NimbleGen]
DNA methylation at proximal promoters facilitates lineage restriction by silencing cell-type specific genes. However, euchromatic DNA methylation frequently occurs in regions outside promoters. The functions of such non-proximal promoter DNA methylation are unclear. Here we show that the de novo DNA...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-22475 | biostudies-arrayexpress
TranscriptomicsExpression data from adult wistar female rat 5mm spinal cord tissue
We used microarray gene expression analyses to unveil the mechanisms underlying NT-3-chitosan-induced spinal cord regeneration. Complete transaction of thoracic spinal cord at T7/8 was performed, with a 5 mm segment of the spinal cord being removed. The emptied space where either refilled with a 5mm...
ORGANISM(S): Rattus norvegicus 
2015-11-02 | E-GEOD-69334 | biostudies-arrayexpress
TranscriptomicsMurine postnatal subventricular zone (SVZ) neural stem cells (NSCs): Wild-type (WT) vs. Dnmt3a-null (KO)
Transcriptional profiling of mouse postnatal SVZ NSCs comparing WT NSCs with KO NSCs under proliferating/undifferentiated states as well as differentiating conditions. Goal was to determine Dnmt3a-dependent gene expression changes in postnatal SVZ NSCs Two-condition experiment with a dye-swap design...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-22473 | biostudies-arrayexpress
TranscriptomicsLncRNA Expression Discriminates Karyotype and Predicts Survival in B-lymphoblastic Leukemia (Agilent)
Long non-coding RNAs (lncRNAs) have been found to play a role in gene regulation with dysregulated expression in various cancers. The precise role that lncRNA expression plays in the pathogenesis of B-acute lymphoblastic leukemia (B-ALL) is unknown. Therefore, unbiased microarray profiling was perfo...
ORGANISM(S): Homo sapiens 
2015-02-05 | E-GEOD-65645 | biostudies-arrayexpress
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