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TranscriptomicsThe Transcriptome of Nrf2-Deficient Mice in Cigarette Smoke-Induced Emphysematous Changes
Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases. Because of its emerging central role in orchestrating the gener...
ORGANISM(S): Mus musculus 
2010-02-27 | E-GEOD-18344 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in lung tissue of rats following exposure to mainstream cigarette smoke
Expression data from rats exposed to cigarette smoke (CS) at three concentrations (sham, 300 µgTPM/l and 600 µgTPM/l) for 13 weeks (5d/week; 2hrs/day) after three different recovery times (2hrs, 6hrs and 20hrs after last treatment); lung tissue Keywords: recovery time course and dose dependency Male...
ORGANISM(S): Rattus norvegicus 
2006-07-27 | E-GEOD-4516 | biostudies-arrayexpress
TranscriptomicsAIR100 SysBio Approach
Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms, to develop new therapies, and to assess the biological perturbations induced by environmental pollutants. Herein, we further develop this in v...
ORGANISM(S): Homo sapiens 
2012-04-01 | E-MTAB-874 | biostudies-arrayexpress
Transcriptomics28d Rat Inhalation Study
We have performed a 28 days rat inhalation study according to the OECD TG 412 by exposing rats for 28 days to filtered air (sham), or to a low, medium, or high concentration of mainstream (MS) cigarette smoke (CS) from the Reference cigarette 3R4F in addition to MS CS from a prototypic modified risk...
ORGANISM(S): Rattus norvegicus 
2014-05-30 | E-MTAB-1842 | biostudies-arrayexpress
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