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TranscriptomicsDetection of aberrant DNA methylation in colorectal carcinoma samples compared to normal human colon
To globally define methylation-’prone’ and -’protected’ CpG islands in colorectal carcinoma we analyzed the methylation status of 23,000 CpG islands of the human genome in ten coleorectal carcinoma samples as well as normal colon using our previously described methyl-CpG immunoprecipitation ...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17512 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in AML cell lines compared to normal human monocytes
To globally define methylation-’prone’ and -’protected’ CpG islands in leukemia, we analyzed the methylation status of 23,000 CpG islands of the human genome in two acute leukemia cell lines as well as normal blood monocytes using our previously described methyl-CpG immunoprecipitation (MCIp...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17455 | biostudies-arrayexpress
TranscriptomicsDetection of aberrant DNA methylation in acute leukemia samples compared to normal human monocytes
To globally define methylation-’prone’ and -’protected’ CpG islands in leukemia, we analyzed the methylation status of 23,000 CpG islands of the human genome in eight acute leukemia samples as well as normal blood monocytes using our previously described methyl-CpG immunoprecipitation (MCIp)...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-17510 | biostudies-arrayexpress
TranscriptomicsCpG island methylation in colorectal cancer
To globally define methylation-M-bM-^@M-^YproneM-bM-^@M-^Y and -M-bM-^@M-^YprotectedM-bM-^@M-^Y CpG islands in cancer, we analyzed the methylation status of 23,000 CpG islands of the human genome in 19 colorectal carcinoma samples as well as normal colon using our previously described methyl-CpG imm...
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-25221 | biostudies-arrayexpress
TranscriptomicsChromosomal abnormalities in colorectal cancer
Microarray-based comparative genomic hybridization of CRC DNA samples from 17 patients who underwent colon resection for biopsy-proven invasive colorectal adenocarcinoma. Microarray-based comparative genomic hybridization of CRC DNA samples against a common reference.
ORGANISM(S): Homo sapiens 
2012-11-01 | E-GEOD-25228 | biostudies-arrayexpress
GenomicsAn atlas of in vivo transcribed enhancers in human primary cells
Enhancers are powerful regulatory regions, important for development and the maintenance of differentiated cells and tissues. Here, we generate global maps for two enhancer-associated histone marks, H3K4me1 and H3K27ac for a number of major human blood cell types. This data was generated to show tha...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-40668 | biostudies-arrayexpress
TranscriptomicsExpression analysis of dendritic cells, macrophages and monocytes
Expression profiles at different time points during dendritic cell differentiation (induced by specific culture conditions) including monocytes as well as expression profiles between monocytes and completely differentiated cells (macrophages at day7 and dendritic cells at day7, respectively) were co...
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-19236 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukemia cell lines KG-1, U937 and THP-1 vs. normal human blood monocytes
Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor-suppressor genes. Genome wide methylation profiling of myeloid leukemia cell lines identified a large number of genes with aberrantly methylated CpG islands. Comparative ...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3280 | biostudies-arrayexpress
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