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ProteomicsSecretome profiling of Cryptococcus neoformans reveals regulation of a subset of virulence-associated proteins and potential biomarkers by protein kinase A
Background: The pathogenic yeast Cryptococcus neoformans causes life-threatening meningoencephalitis in individuals suffering from HIV/AIDS. The cyclic-AMP/protein kinase A (PKA) signal transduction pathway regulates the production of extracellular virulence factors in C. neoformans, but the influe...
ORGANISM(S): Cryptococcus neoformans var. grubii H99W 
2015-10-13 | PXD002731 | Pride
Quantitative proteomics  fungal pathogenesis  secretome  pka  virulence factors  biomarkers  multiple reaction monitoring 
ProteomicsProteomic profiling of Cryptococcus neoformans
The opportunistic fungal pathogen Cryptococcus neoformans causes life-threatening meningitis in immunocompromised individuals. The expression of virulence factors including capsule and melanin is in part regulated by the cyclic-AMP/Protein Kinase A (PKA) signal transduction pathway. In this study, w...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2016-01-18 | PXD002727 | Pride
Virulence Proteomics Fungal pathogenesis Camp/pka pathway 
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