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TranscriptomicsDazl is required for TET-mediated reprogramming to a naïve pluripotent state
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69357 | biostudies-arrayexpress
TranscriptomicsThe growth factor environment defines distinct pluripotent ground states in novel blastocyst derived stem cells
Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic stem cell lines (ES cells), as well as the post-implantation epiblast, which gives rise to epiblast stem cell lines (EpiSCs). Remarkably, ES cells and EpiSCs display profound differences in the combination of g...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-12519 | biostudies-arrayexpress
ProteomicsSpatial multi-omics in skeletal muscle unravel complex myofiber architecture
Spatial distribution of metabolites and phospholipids in murine tibialis anterior (TA) muscles.
ORGANISM(S): Mus musculus (Mouse) 
2024-09-27 | PXD048809 | Pride
Metabolomics Skeletal muscle Fiber type 
TranscriptomicsDazl is required for TET-mediated reprogramming to a naïve pluripotent state (II)
Embryonic stem cell (ESC) cultures display a heterogeneous gene expression profile, ranging from a pristine naïve pluripotent state to a primed epiblast state. While it is known that the addition of inhibitors of GSK3β and MEK (so-called 2i conditions) push ESC cultures towards a more homogeneous na...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-69356 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl testis RNA-IP)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39545 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl native RNA-IP)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39544 | biostudies-arrayexpress
TranscriptomicsAn RNA-interacting protein network regulates pluripotency in mammalian primordial germ cells (Dazl knockdown)
Primordial germ cells (PGCs) are the embryonic precursors to egg and sperm. When removed from the embryonic gonad, PGCs can give rise to embryonic germ cell lines (EGs), pluripotent stem cells that display most of the characteristics of embryonic stem cells (ESCs) including the ability to form terat...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-39535 | biostudies-arrayexpress
GenomicsThe pluripotent genome in three dimensions is shaped around pluripotency factors
It is becoming increasingly clear that the shape of the genome importantly influences transcription regulation. Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) were recently shown to organize their chromosomes into topological domains that are largely invariant between cell types. ...
ORGANISM(S): Mus musculus 
2013-07-24 | E-GEOD-37275 | biostudies-arrayexpress
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