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TranscriptomicsBeclin-1 is dispensable for chromosome congression and proper outer kinetochore assembly
Chromosomal instability (CIN) is defined by the propensity to acquire structural and/or numerical aberration in the normal cellular karyotype and is often associated with cancer. Autophagy is a catabolic process that leads to the recycling of cellular components that may positively or negatively imp...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-69052 | biostudies-arrayexpress
TranscriptomicseIF3a in Urinary Bladder Cancer M-bM-^@M-^S in vivo and in vitro insights
The eukaryotic translation initiation factor (eIF) 3a is described in various tumor entities as potential tumor marker involved in development and progression of cancer. eIF3a is the largest subunit of the eIF3 complex, a key functional entity in 80S establishment and translation initiation. We hypo...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-45636 | biostudies-arrayexpress
TranscriptomicsSOCS2 expression correlates with tumor malignancy, exerts growth promoting effects and is enhanced by androgens in prostate cancer
Deregulation of cytokine- and growth factor signaling due to altered expression of endogenous regulators is well recognized in prostate and other cancers. Suppressor of cytokine signaling 2 (SOCS2) is a key regulator of growth hormone, IGF and prolactin signaling, that have been implicated in carcin...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-50936 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood lymphoblasts purified at three time points from childhood ALL samples (0h, 6-8h, 24h after treatment with prednisolone
Glucocorticoids (GC) are in most chemotherapy protocols for lymphoid malignancies, particularly childhood acute lymphoblastic leukaemia (ALL) for their ability to induce apoptosis in malignant blast. The underlying mechanism, however, has so far only been investigated in model systems. This study co...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2842 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of thymic mouse cells
Glucocorticoids (GC) are in most chemotherapy protocols for lymphoid malignancies, particularly childhood acute lymphoblastic leukaemia (ALL) for their ability to induce apoptosis in malignant blast. The underlying mechanism, however, has so far only been investigated in model systems. This study co...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2843 | biostudies-arrayexpress
TranscriptomicsLoss-of-function of MYO5B induces epithelial cell scattering in enterocytes
A non-functional myosin Vb motor in duodenal enterocytes results in disruption of epithelial cell polarity characterized by complete loss of microvilli and mislocalization of apical brush border proteins in the cytoplasm which finally cause a devastating disease in neonates with severe malabsorption...
ORGANISM(S): Homo sapiens 
2013-03-14 | E-GEOD-45134 | biostudies-arrayexpress
TranscriptomicsDifferential neuronal targeting of a new and 2 known calcium channel M-NM-24 subunit splice variants correlates with their regulation of gene expression
The M-NM-2 subunits of voltage-gated calcium channels regulate surface expression and gating of CaV1 and CaV2 M-NM-11 subunits, and thus contribute to neuronal excitability, neurotransmitter release and calcium-induced gene regulation. In addition certain M-NM-2 subunits are targeted into the nucleu...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-50822 | biostudies-arrayexpress
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