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Dynamics of genomic clones in breast cancer patient xenografts at single cell resolution
Human cancers, including breast cancers, are comprised of clones differing in mutation content that evolve dynamically in space and time following principles of Darwinian evolution, underpinning important emergent features such as drug resistance and metastasis. Human breast cancer xenoengraftment i...
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Mutational landscapes of primary triple negative breast cancers - WGS
Mutational landscapes of primary triple negative breast cancers - RNA seq
tumour samples using Affymetrix Genome-Wide SNP6.0 arrays
Mutational landscapes of primary triple negative breast cancers - Exomes
Primary triple negative breast cancers (TNBC) represent approximately 16% of all breast cancers and are a tumour type defined by exclusion,for which comprehensive landscapes of somatic mutation have not been determined. Here we show in 104 early TNBC cases, that at the time of diagnosis these cancer...
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