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MetabolomicsInteraction between Cervical Microbiota and Host Gene Regulation in Caesarean Section Scar Diverticulum

Cesarean section scar diverticulum (CSD) has become a formidable obstacle preventing women receiving CS from reproducing. However, the pathogenesis of CSD remains unexplored. In this study, we characterized the cervical microbiota, metabolome and endometrial transcriptome of women with CSD. Based...

2022-07-25 | MTBLS4967 | MetaboLights
ProteomicsCompetitive Binding and Molecular Crowding Regulate the Cytoplasmic Interactome of Non-Viral Polymeric Gene Delivery Vectors
In contrast to the processes controlling the complexation, targeting and uptake of polycationic gene delivery vectors, the molecular mechanisms regulating their cytoplasmic dissociation remains poorly understood. Upon cytosolic entry, vectors become exposed to a complex, concentrated mixture of mole...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028512 | Pride
Gene delivery Rna delivery Polymer brush Proteomics Cytosolic interactome Polycationic vector Lc-ms/ms 
TranscriptomicsIntracellular Signaling Pathways in Nonviral Gene Delivery: Gene Expression Profiles in Transfected Cells
Analysis of gene expression changes due to nonviral gene delivery of DNA lipoplexes versus control in human HEK293T cells. Human HEK293T RNA was isolated from control, non-transfected cells (CTR) and transfected (GFP) samples for analysis on microarrays with three biological replicates.
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-20615 | biostudies-arrayexpress
UnknownA practical approach for adoption of a hub and spoke model for cell and gene therapies in low- and middle-income countries: framework and case studies.
Not available
S-EPMC10788266 | biostudies-literature
TranscriptomicsApelin-VEGF-C mRNA delivery as therapeutic for the treatment of secondary lymphedema
Secondary lymphedema (LD) corresponds to a severe lymphatic dysfunction leading to the accumulation of fluid and fibrotic adipose tissue in a limb. Here, we identified apelin (APLN) as a powerful molecule for regenerating lymphatic function in LD. We identified the loss of APLN expression in lymphed...
ORGANISM(S): Homo sapiens 
2023-10-20 | E-MTAB-13381 | biostudies-arrayexpress
UnknownSerotype survey of AAV gene delivery via subconjunctival injection in mice.
Not available
S-EPMC11610513 | biostudies-literature
UnknownPolymerized Selenium Nanoparticles for Folate-Receptor-Targeted Delivery of Anti-Luc-siRNA: Potential for Gene Silencing.
Not available
S-EPMC7235796 | biostudies-literature
ProteomicsStructuring lipid nanoparticles, DNA, and protein corona into stealth bionanoarchitectures for in vivo gene delivery
Lipid nanoparticles (LNPs) play a crucial role in addressing genetic disorders, and cancer, and combating pandemics such as COVID-19 and its variants. Yet, in contrast remarkable achievements in siRNA and mRNA delivery, the ability of LNPs to effectively encapsulate large-size DNA molecules remains ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD054751 | Pride
Protein corona Lipid nanoparticles Dna 
GenomicsTargeted immunosuppression enhances repeated gene delivery
Targeted immunosuppression enhances repeated gene delivery
PRJNA823700 | ENA
GenomicsOptimizing Non-Viral Gene Delivery to T Cells with Lipofectamine LTX
Optimizing Non-Viral Gene Delivery to T Cells with Lipofectamine LTX
PRJNA637099 | ENA
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