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ProteomicsEvolutionary Instability of CUG-Leu in the Genetic Code of Budding Yeasts
The standard genetic code is almost universal, and the evolutionary factors that caused a few organisms to deviate from it are poorly understood. We report that three independent changes of the genetic code occurred during the evolution of budding yeasts, each of which was a reassignment of the codo...
ORGANISM(S): Komagataella phaffii Babjeviella inositovora [Candida] boidinii Lipomyces starkeyi Kuraishia capsulata Nakazawaea wickerhamii Peterozyma xylosa Ascoidea rubescens Citeromyces matritensis Pachysolen tannophilus Saturnispora dispora Tortispora caseinolytica Ambrosiozyma philentoma Candida parapsilosis Pichia kudriavzevii Cyberlindnera jadinii Ogataea polymorpha Saccharomycopsis capsularis 
2018-05-21 | PXD008827 | Pride
Genetic code yeast cug 
ProteomicsYeast genetic codes - Endogenous Stochastic Decoding of the CUG Codon by Competing Ser- and Leu-tRNAs in Ascoidea asiatica
While the “universal” genetic code is now known not to be universal, and stop codons can have multiple meanings, one regularity remains, namely that for a given sense codon there is a unique translation. Examining CUG usage in yeasts that have transferred CUG away from leucine, we here report the fi...
ORGANISM(S): Saccharomycopsis fibuligera Ascoidea rubescens DSM 1968 Clavispora lusitaniae ATCC 42720 Babjeviella inositovora NRRL Y-12698 Saccharomycopsis malanga Ascoidea asiatica Nakazawaea peltata 
2018-06-13 | PXD009494 | Pride
Ascoidea Clavispora Saccharomycopsis Nakazawaea Babjeviella 
ProteomicsPachysolen tannophilus LC-MSMS
The genetic code is the cellular translation table for the conversion of nucleotide sequences into amino acid sequences. Changes to the meaning of sense codons would introduce errors into almost every translated message and are expected to be highly detrimental. However, reassignment of single or mu...
ORGANISM(S): Pachysolen tannophilus NRRL Y-2460 
2016-05-06 | PXD003898 | Pride
Yeast cug codon usage 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation 5B; S. capsularis CBS5638 Sporulation
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044772 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 4B; S. capsularis CBS5064 Sporulation
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044742 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 7B; S. fermentans CBS7830 Sporulation
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044719 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation 4A; S. capsularis CBS5064 Vegetative growth
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044788 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 6B; S. capsularis CBS7262 Sporulation
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044786 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 5A; S. capsularis CBS5638 Vegetative growth
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044763 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
ProteomicstRNA-Leu(CAG) gene is conserved in most Saccharomycopsis yeast species but is non-essential and does not compete with tRNA-Ser(CAG) in translation Dataset 7A S. fermentans CBS7830 Vegetative growth
In the yeast genera Saccharomycopsis and Ascoidea, nuclear genes use a non-standard genetic code in which CUG codons are translated as serine instead of leucine, due to the presence of a tRNA-Ser with the unusual anticodon CAG. However, some species in this ‘CUG-Ser2’ clade also contain an ancestral...
ORGANISM(S): Saccharomycopsis capsularis 
2024-10-17 | PXD044693 | Pride
Proteomics Mass spectrometry Eukaryote genome evolution Saccharomycopsis 
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