Genetic inheritance

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Unknown (4743)
Transcriptomics (894)
Genomics (620)
Metabolomics (51)
Proteomics (27)
Methylation profiling (24)
Genomic (18)
Other (11)
Models (1)

Organisms

Homo sapiens (438)
Mus musculus (308)
Drosophila melanogaster (53)
Saccharomyces cerevisiae (47)
Rattus norvegicus (47)
Caenorhabditis elegans (46)
Arabidopsis thaliana (40)
Sus scrofa (13)
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Zea mays (8)
Oryza sativa Indica Group (5)
Canis lupus familiaris (5)
Schizosaccharomyces pombe (5)
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Ovis aries (4)
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Triticum aestivum (3)
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Xenopus laevis (2)
Macaca fascicularis (2)
Oryza sativa (2)
Anopheles gambiae (2)
Saccharomyces cerevisiae S288C (2)
Hordeum vulgare (2)

Organisms

Homo sapiens (79)
Mus musculus (36)
Caenorhabditis elegans (29)
Drosophila melanogaster (13)
Rattus norvegicus (10)
Arabidopsis thaliana (8)
Danio rerio (5)
Saccharomyces cerevisiae (4)
Canis lupus familiaris (3)
Zea mays (3)
Gallus gallus (3)
Salvelinus fontinalis (2)
Lathyrus oleraceus (2)
Brassica napus (2)
Schizosaccharomyces pombe (2)
Gossypium hirsutum (2)
Laupala (1)
Pediculus humanus (1)
Utterbackia imbecillis (1)
Leishmania major strain Friedlin (1)
Rosa multiflora (1)
Oncorhynchus keta (1)
Sequoia sempervirens (1)
Antirrhinum (1)
Fragaria vesca subsp. bracteata (1)
Sporobolus michauxianus (1)
Tachycineta bicolor (1)
Marasmius oreades (1)
Fusarium graminearum PH-1 (1)
Gossypium hirsutum subsp. hirsutum (1)

Repository

biostudies-arrayexpress (851)
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geo (175)
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pride (16)
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Tissue

Cerebrospinal fluid (2)
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Testis (1)

Disease

Normal (4)
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Amyotrophic lateral sclerosis (1)
HIV-1 seropositive (1)
Replicate control (1)
Rett syndrome (1)
Mitochondrial complex I deficiency (1)
Parkinson's disease (1)
Short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome (1)
NGT (1)
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Diabetes mellitus type 2 (1)
Albright's hereditary osteodystrophy (1)
Neuroblastoma (1)
Urticaria (1)

Technology Type

Mass spectrometry (31)
Mass spectrometry assay (19)
Mass Spectrometry (16)
Illumina HiSeq 2000 (12)
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ILLUMINA, Illumina HiSeq 2500 (2)
Data-dependent acquisition (2)
Data-independent acquisition (2)
Illumina HiSeq 2000, PacBio RS II (1)
Illumina HiSeq 2000 (ILLUMINA), Illumina HiSeq 1500 (ILLUMINA) (1)
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HiSeq X Ten (1)
ZCall, Illumina HumanExome-12v1_A-GenCall (1)
HumanOmniExpress-12 v1.1 BeadChip-GenCall (1)
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Illumina HiSeq 2500, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, Illumina HiSeq 2500 (1)
Illumina Infinium 1.2M (1)
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Illumina Genome Analyzer II (1)
NMR spectroscopy (1)
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SRM/MRM (1)
SWATH MS (1)

Instrument Platform

Illumina NovaSeq 6000 (103)
NextSeq 500 (26)
Illumina HiSeq 4000 (22)
Illumina HiSeq 2500 (20)
Illumina NovaSeq X (17)
NextSeq 550 (10)
Illumina HiSeq 2000 (10)
NextSeq 2000 (5)
Illumina Genome Analyzer IIx (4)
DNBSEQ-G400 (4)
10x Chromium Controller (3)
Affymetrix Fluidics Station 400 (3)
MA900, Sony (2)
Agilent high resolution C scanner (2)
10X Genomics Chromium (2)
Axon GenePix 4000B scanning hardware (2)
None (2)
R (2)
Illumina HiSeq 1000 (2)
Illumina MiSeq (2)
DNBelab C Series High-throughput Single-cell RNA Library Preparation Set V3.0 (MGI Tech) (1)
DNBelab C-TaiM droplet generator (MGI Tech) (1)
Avatarget 12-well dual-chamber organ-on-chip system; AvatarFlow Organ Chip Flow Initiation Controller System (Avatarget Co., Ltd., Suzhou, China) (1)
Nanodrop (1)
10x Genomics Chromium Controller, PCR thermocycler, Agilent 2100 Bioanalyzer with High Sensitivity DNA chip (for quality control) (1)
Water bath (for enzymatic dissociation), cell strainer (70-μm), benchtop centrifuge, automated cell counter/hemocytometer, biological safety cabinet (1)
Sterile surgical instrument set (scalpels, tissue forceps, dissection scissors), animal operating table, biological safety cabinet (1)
Chromium Controller, 10x Genomics and Chromium X, 10x Genomics (1)
Chromium Controller, 10x Genomics and Chromium X, 10x Genomics (1)
Cell culture (1)

Publication Date

2010 (96)
2026 (90)
2011 (85)
2012 (84)
2025 (75)
2015 (71)
2014 (66)
2013 (66)
2024 (52)
2009 (51)
2016 (47)
2023 (44)
2008 (44)
2022 (41)
2021 (37)
2020 (33)
2007 (30)
2018 (21)
2017 (21)
2019 (19)
2006 (13)
2005 (8)
2004 (8)

CHEBI ID

CHEBI:30769 (15)
CHEBI:6650 (12)
CHEBI:15891 (11)
CHEBI:30915 (10)
CHEBI:32816 (9)
CHEBI:28300 (8)
CHEBI:25017 (8)
CHEBI:15428 (8)
CHEBI:15741 (8)
CHEBI:18012 (8)
CHEBI:16027 (8)
CHEBI:78320 (8)
CHEBI:17596 (8)
CHEBI:15756 (8)
CHEBI:18237 (7)
CHEBI:22660 (7)
CHEBI:17234 (7)
CHEBI:16708 (7)
CHEBI:17562 (7)
CHEBI:28842 (7)
CHEBI:16335 (7)
CHEBI:27266 (7)
CHEBI:17084 (7)
CHEBI:16704 (7)
CHEBI:16919 (7)
CHEBI:15354 (7)
CHEBI:17368 (7)
CHEBI:17822 (6)
CHEBI:17202 (6)
CHEBI:15978 (6)

Metabolite Name

Uracil (13)
Choline (13)
L-Tyrosine (13)
Betaine (11)
Taurine (11)
Adenosine (11)
L-Phenylalanine (11)
Inosine (11)
Propionylcarnitine (10)
L-Proline (10)
L-Histidine (10)
Sphinganine (10)
Xanthine (10)
Creatine (10)
Thymine (9)
L-Arginine (9)
Pantothenic acid (9)
Guanine (9)
Riboflavin (9)
L-Tryptophan (9)
Guanosine (9)
Creatinine (9)
Hypoxanthine (9)
Indole (8)
Cytosine (8)
AMP (7)
Glutamine (7)
L-Alanine (7)
S-Adenosylhomocysteine (7)
Niacinamide (7)

IsPrivate

False (1)

First Public Date

2024 (52)
2025 (46)
2026 (36)
2023 (32)
2020 (32)
2013 (32)
2015 (27)
2022 (26)
2021 (24)
2014 (23)
2017 (22)
2018 (21)
2019 (19)
2016 (15)
2011 (3)
2012 (1)

Classification

fungi (1)
protozoa (1)

Modelling Approach

Ordinary differential equation model (1)

Study type

Transcription profiling by array (398)
RNA-seq of coding RNA (120)
RNA-seq of coding RNA from single cells (118)
RNA-seq of non coding RNA (27)
ChIP-chip by tiling array (23)
Comparative genomic hybridization by array (23)
ChIP-seq (22)
Methylation profiling by array (18)
DNA-seq (11)
Methylation profiling by high throughput sequencing (10)
Other (9)
Unknown experiment type (8)
Single nucleus RNA sequencing (7)
RNA-seq of total RNA (7)
Cell line - High-throughput sequencing (6)
Transcription profiling by SAGE (4)
ChIP-chip by array (4)
Genotyping by array (4)
Animal - High-throughput sequencing (3)
Transcription profiling by tiling array (3)
Bisulfite-seq (3)
Human - Single-cell sequencing (2)
High-throughput sequencing (2)
Transcription profiling by RT-PCR (2)
Spatial transcriptomics by high-throughput sequencing (2)
ATAC-seq (2)
CUT&RUN (2)
RAN-seq of total RNA from single cells (1)
Animal - Methylation microarray (1)
Cell line - Single-cell sequencing (1)

Release Date

2023 (498)
2022 (489)
2021 (479)
2025 (407)
2020 (364)
2024 (358)
2019 (331)
2018 (305)
2015 (274)
2016 (272)
2017 (269)
2014 (247)
2013 (213)
2012 (180)
2011 (173)
2010 (169)
2009 (115)
2026 (100)
2008 (100)
2007 (74)
2006 (42)
2005 (29)
2004 (21)
2003 (17)
2000 (16)
2002 (15)
2001 (13)
1999 (9)
1998 (6)
1997 (3)

Lab affiliation

Head of Laboratory of Neuro-Oncology, Neurology, Clinical & Cancer Proteomics (2)
1. Institute for Genome Stability in Aging and Disease, Medical Faculty, University of Cologne, Germany 2. Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany (1)
Associate professor, School of Biological Sciences, Seoul National University (1)
Charite Universitaetsmedizin Berlin, Department of Dermatology and Allergy; Autoinflammation Reference Center (ARC2) (1)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (1)
Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada. (1)
Department of Biology, University of North Dakota, Grand Forks, ND 58202, USA. (1)
Head of the Curie Institute Mass Spectrometry Platform (1)
Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany; Institute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany; Cardio-Pulmonary Institute, Frankfurt am Main, Germany (1)
Institute of Molecular Biology Ackermannweg 4 55128 Mainz (1)
Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. (1)
Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. Otto-Hahn-Straße 6b 44227 Dortmund, Germany P: +49 (0)2 31.13 92-100 F: +49 (0)2 31.13 92-200 Albert.Sickmann@isas.de www.isas.de (1)
Max Delbrück Center Robert-Rössle-Straße 10 13125 Berlin, Germany (1)
Mitochondrial Research Group, Faculty of Medical Sciences, Newcastle University, UK (1)
The University of Sydney, School of Life and Environmental Sciences, Charles Perkins Centre, Sydney, New South Wales, Australia. (1)

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Interaction of Genetic Variants Activates Latent Metabolic Pathways in Yeast

Genetic interactions are fundamental to the architecture of complex traits, yet the molecular mechanisms by which variant combinations influence cellular pathways remain poorly understood. Here, we answer the question of whether interactions between genetic variants can activate unique pathways a...

2025-07-22 | MTBLS12761 | MetaboLights

Genetic stability and germ cell epigenetic instability in the Mtrr mouse model of transgenerational epigenetic inheritance.

Folate metabolism is important for DNA synthesis and repair through its role in the synthesis of the nucleotide thymidine. Mice with a hypomorphic mutation in the gene Mtrr have disrupted folate metabolism and show transgenerational inheritance of developmental abnormalities. We sought to explore if...

ORGANISM(S): Mus musculus

2021-04-06 | E-MTAB-8513 | biostudies-arrayexpress

Genetic Ablation of Sfxn5 Induces Mitochondrial Dysfunction and Precipitates Lethal Metabolic Crisis in Mice

Mitochondrial disorders frequently manifest with life-threatening hepatic metabolic crises. Using a global Sfxn5-knockout mouse model, we investigated the systemic consequences of disrupting this mitochondrial inner-membrane transporter through integrated biochemical, metabolomic, histological, and ...

2026-05-30 | MTBLS14628 | MetaboLights

A nuclear Argonaute promotes germline immortality and epigenetic inheritance across generations

dsRNA-mediated gene silencing (RNAi) can be inherited for multiple generations in C. elegans. To understand this process we conducted a genetic screen for animals defective for transmitting RNAi silencing signals to future generations. This screen identified the gene heritable RNAi defective (hrde)-...

ORGANISM(S): Caenorhabditis elegans

2012-07-30 | E-GEOD-38041 | biostudies-arrayexpress

Germ cell epigenetic instability in the Mtrr mouse model of transgenerational epigenetic inheritance

Folate metabolism is important for the generation of methyl groups required for cellular methylation reactions. Mice with a hypomorphic mutation in the gene Mtrr have disrupted folate metabolism and show transgenerational inheritance of developmental abnormalities. We sought to explore if DNA methyl...

ORGANISM(S): Mus musculus

2021-04-06 | E-MTAB-8533 | biostudies-arrayexpress

Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease [NimbleGen]

The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestatin...

ORGANISM(S): Rattus norvegicus

2014-07-17 | E-GEOD-59277 | biostudies-arrayexpress

Thermosensory neurons control genetic inheritance through regulation of germline transposons

PRJNA1191416 | ENA

Genetic-epigenetic interactions in paternal transgenerational inheritance of metabolic disorders

PRJNA737357 | ENA

Environmentally induced epigenetic transgenerational inheritance of ovarian disease

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Rattus norvegicus

2014-07-17 | E-GEOD-59278 | biostudies-arrayexpress

PRC2 mediated paternal epigenetic inheritance

PRC2 mediated paternal epigenetic inheritance - E15.5