Sort   by:  
 Page size 
MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
TranscriptomicsDifferentiation of Mammary Tumors and Reduction in Metastasis Upon Malat1 LncRNA Loss
Genome-wide analyses have identified thousands of long non-coding RNAs (lncRNAs). Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers. Here we report that genomic loss, as well as systemic knockdown of Mal...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-67647 | biostudies-arrayexpress
MetabolomicsCreation and Characterization of a Genomically Hybrid Strain in the Nitrogen-Fixing Symbiotic Bacterium Sinorhizobium meliloti
Many bacteria, often associated with eukaryotic hosts and of relevance for biotechnological applications, harbor a multipartite genome composed of more than one replicon. Biotechnologically relevant phenotypes are often encoded by genes residing on the secondary replicons. A synthetic biology approa...
2021-03-17 | MTBLS576 | MetaboLights
TranscriptomicsGlobal consequences of phosphatidylcholine reduction in Bradyrhizobium japonicum
Analysis of a Bradyrhizobium japonicum pmtA mutant. PmtA catalyzes the first of three consecutive methylation reactions leading to phosphatidylcholine (PC) formation in B. japonicum. Disruption of the pmtA gene results in a significantly reduced PC content causing a defect in symbiosis with the soyb...
ORGANISM(S): Bradyrhizobium japonicum 
2008-04-17 | E-GEOD-11187 | biostudies-arrayexpress
TranscriptomicsMechanism for Fe(III) Reduction in Pelobacter carbinolicus
Pelobacter carbinolicus is phylogenetically intertwined with the Geobacteraceae, a family of deltaproteobacteria which couple oxidation of organic compounds to Fe(III) reduction. Whereas Geobacter species completely oxidize organic compounds to CO2, Pelobacter species either ferment or oxidize shor...
ORGANISM(S): Pelobacter carbinolicus 
2008-05-21 | E-GEOD-8338 | biostudies-arrayexpress
ProteomicsMini-Bacillus - Large-scale reduction of the Bacillus subtilis genome: Consequences for the transcriptional network, resource allocation, and metabolism
In this study, we have applied the top-down approach to reduce the genome of B. subtilis in order to obtain minimal strains with robust growth on complex medium at 37°C. For this purpose, we have evaluated the function of each gene of the B. subtilis genome and identified essential, important and di...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2016-12-06 | PXD004565 | Pride
Dia Bacillus subtilis Lc-ms/ms 
ProteomicsEnhanced protein secretion in reduced genome strains of Streptomyces lividans
S. lividans TK24 is a popular host for the production of small molecules and for the secretion of heterologous proteins. TK24 has a large genome with at least 29 secondary metabolite gene clusters that are non-essential for viability and undergo complex regulation. To optimize heterologous protein s...
ORGANISM(S): Streptomyces lividans TK24 
2024-01-26 | PXD040146 | Pride
Reduced genome strains Proteomics Heterologous secretion Transcriptomics Secretome 
UnknownThe Effects of Signal Erosion and Core Genome Reduction on the Identification of Diagnostic Markers.
Not available
S-EPMC5030356 | biostudies-literature
GenomicsGenome-Wide DNA Methylation Profiles in Hematopoietic Stem and Progenitor Cells Reveal Over-Representation of ETS Transcription Factor Binding Sites
DNA methylation is an essential epigenetic mark that is required for normal development. Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment reveals that methylation is critical for hematopoietic differentiation. To better understand the role of DNA methylation in he...
ORGANISM(S): Mus musculus 
2012-06-01 | E-GEOD-38354 | biostudies-arrayexpress
TranscriptomicsIncreased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA
Transcriptome analysis is of great interest in clinical research, where significant differences between individuals can be translated into biomarkers of disease. Although next generation sequencing provides robust, comparable and highly informative expression profiling data, with several million of ...
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33701 | biostudies-arrayexpress
Sort   by:  
 Page size