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MetabolomicsGenome-scale metabolic modelling of responses to polymyxins in Pseudomonas aeruginosa
Background: Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics...
2018-02-28 | MTBLS630 | MetaboLights
MetabolomicsGenome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a major risk factor leading to chronic liver disease and type 2 diabetes. Here we chart liver metabolic activity and functionality in NAFLD by integrating global transcriptomic data, from human liver biopsies, and metabolic flux data, measured across the ...
2016-12-15 | MTBLS298 | MetaboLights
MetabolomicsModel-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation
Macrophages are central players in immune response, manifesting divergent phenotypes to control inflammation and innate immunity through release of cytokines and other signaling factors. Recently, the focus on metabolism has been reemphasized as critical signaling and regulatory pathways of human pa...
2012-09-05 | MTBLS23 | MetaboLights
TranscriptomicsInterrogation of global mutagenesis data with a genome scale model of Neisseria meningitidis to assess gene fitness in vitro and in sera.
Background Neisseria meningitidis is an important human commensal and pathogen that causes several thousand deaths each year, mostly in young children. How the pathogen replicates and causes disease in the host is largely unknown, particularly the role of metabolism in colonization and disease. Com...
ORGANISM(S): Neisseria meningitidis 
2012-01-23 | E-BUGS-129 | biostudies-arrayexpress
MetabolomicsModel-guided development of evolutionarily stable yeast chassis for dicarboxylic acids production

Chassis strain suitable for producing multiple compounds is a central concept in synthetic biology. Design of a chassis using computational, first-principle, models is particularly attractive due to the predictability and control it offers, including against phenotype reversal due to adaptive mut...

2021-07-19 | MTBLS2007 | MetaboLights
ModelsGenome-scale metabolic model of Enterococcus faecalis V583
Genome-scale metabolic model of Enterococcus faecalis V583
2015-10-01 | 180 | FAIRDOMHub
ModelsSmallbone2013 - Yeast metabolic model with linlog rate law
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000471 | BioModels
ModelsSmallbone2013 - Yeast metabolic model with modular rate law
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000472 | BioModels
ModelsSmallbone2013 - E.coli metabolic model with linlog rate law
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000469 | BioModels
ModelsSmallbone2013 - E.coli metabolic model with modular rate law
Kieran Smallbone & Pedro Mendes. Large-Scale Metabolic Models: From Reconstruction to Differential Equations. Industrial Biotechnology 9, 4 (2013). Genome-scale kinetic models of metabolism are important for rational design of the metabolic engineering required for industrial biotechnology applicat...
2024-09-02 | BIOMD0000000470 | BioModels
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