Genome-wide crispr-cas9 screen

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Genome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells

To identify new therapeutic targets for Glioblastoma (GBM), we performed genome-wide CRISPR-Cas9 "knockout" (KO) screens in patient-derived GBM stem-like cells (GSCs) and human neural stem/progenitors (NSCs), non-neoplastic stem cell controls, for genes required for their in vitro growth. ...

ORGANISM(S): Homo sapiens

2016-02-15 | E-GEOD-70038 | biostudies-arrayexpress

Genome-wide CRISPR-Cas9 screen (TKOv3) data on SUN2 degradation

PRJEB54102 | ENA

Genome-wide CRISPR-Cas9 knockout screen in MCF10A with ATP-competitive inhibition of CDC7 (XL-413)

The coordinated activation of DNA replication origins is important for efficient DNA synthesis and genome stability. S-phase cyclin dependent kinases (CDKs) together with CDC7 kinase, are essential to origin activation by converting the pre-replicative complex into a fully active helicase. To identi...

ORGANISM(S): Homo sapiens

2026-09-30 | E-MTAB-17434 | biostudies-arrayexpress

Genome-wide CRISPR-Cas9 screen to identify SFV4 receptor

PRJNA1194606 | ENA

Genome-wide CRISPR/Cas9 screen in HEC1B isogenic cell lines

PRJNA1195677 | ENA

CRISPR-Cas9 RBM10 synthetic lethality screen

PRJEB60386 | ENA

Genome-wide CRISPR-Cas9 screen in isogenic parental and RBM10-KO HCC827 cells

PRJEB71144 | ENA

Genome-wide CRISPR-Cas9 screen in isogenic parental and RBM10-KO HCC827 cells

Genome-wide CRISPR-Cas9 knockout screen using TKOv1 sgRNA library performed in isogenic RBM10-proficient and RBM10-deficient HCC827 cells.

ORGANISM(S): Homo sapiens

2024-03-01 | E-MTAB-13626 | biostudies-arrayexpress

Genome-wide CRISPR/Cas9 loss-of-function screen for prostate cancer cell line

PRJNA917317 | ENA

In vivo CRISPR/Cas9 screen to identify candidate therapeutic gene targets to enhance docetaxel efficacy in prostate cancer

Docetaxel chemotherapy in metastatic prostate cancer offers only a modest survival benefit due to emerging resistance. To identify candidate therapeutic gene targets, we applied a murine prostate cancer orthograft model that recapitulates clinical invasive prostate cancer in a genome-wide CRISPR/Cas...

ORGANISM(S): Mus musculus

2020-10-07 | E-MTAB-9482 | biostudies-arrayexpress

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