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TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (miRNA)
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72014 | biostudies-arrayexpress
TranscriptomicsExpression Profiles of HepG2 cells treated with genotoxic and non-genotoxic agents
The lack of accurate in vitro assays for predicting in vivo toxicity of chemicals together with new legislations demanding replacement and reduction of animal testing has triggered the development of alternative methods. This study aimed at developing a transcriptomics-based in vitro prediction assa...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-28878 | biostudies-arrayexpress
TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (mRNA)
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72081 | biostudies-arrayexpress
GenomicsGenotoxicity of nitrosamines
Genotoxicity of nitrosamines
PRJNA434755 | ENA
TranscriptomicsQuercetin showed no genotoxicity by transcriptomic analysis in liver and small intestine of mice
Given the positive results of quercetin in in vitro genotoxicity studies, it is of interest to test the in vivo genotoxicity of this important dietary flavonoid, especially considering possible high intake by widely available supplements. In the present study quercetin was tested in a transcriptomic...
ORGANISM(S): Mus musculus 
2015-10-01 | GSE63227 | GEO
GenomicsUnlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals I
Unlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals I
PRJNA1006335 | ENA
GenomicsUnlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals II
Unlocking the power of transcriptomic biomarkers in qualitative and quantitative genotoxicity assessment of chemicals II
PRJNA1006345 | ENA
GenomicsOrientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche
Orientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche
PRJNA1295518 | ENA
Genomics
In vivo genotoxicity assesment of NDEA in mouse
PRJNA1055433 | ENA
GenomicsApplication of a New Approach Methodology (NAM)-based Strategy for Genotoxicity Assessment of Data-poor Compounds
Application of a New Approach Methodology (NAM)-based Strategy for Genotoxicity Assessment of Data-poor Compounds
PRJNA880874 | ENA
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