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GenomicsGenentech Colon Cancer Screen
Identifying and understanding changes in cancer genomes is essential for the development of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary human colon tumours by applying next-generation sequencing to characterize their exomes, transcriptomes and copy-number alte...
EGAS00001000288 | EGA
TranscriptomicsTranscription profiling of various types of murine cerebellum cells to investigate the pre-neoplastic stage of medulloblastoma
SUMMARY; Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here we identify a pre-neoplastic stage of medulloblas...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2426 | biostudies-arrayexpress
GenomicsGenetic and epigenetic determinants of neurogenesis and myogenesis [ChIP-seq]
The regulatory networks of differentiation programs have been partly characterized; however, the molecular mechanisms of lineage-specific gene regulation by highly similar transcription factors remain largely unknown. Here we compare the genome-wide binding and transcription profiles of NEUROD2-medi...
ORGANISM(S): Mus musculus 
2012-03-26 | E-GEOD-34906 | biostudies-arrayexpress
TranscriptomicsRNAi knock down using siRNAs targeting PROX1 or GFP in human colon carcinoma cells
siRNA transfection using either two different siRNAs targeting PROX1 or GFP
ORGANISM(S): Homo sapiens 
2008-09-03 | E-MEXP-1422 | biostudies-arrayexpress
TranscriptomicsExpression analysis of C. elegans wild-type N2 and rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutants
Investigation of whole genome gene expression level changes in C. elegans rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutant compared to the wild-type N2 strain. The mutants have altered longevity phenotypes. The mutants analyzed in this study are further described in Di Chen, Patrick Wai-...
ORGANISM(S): Caenorhabditis elegans 
2013-11-14 | E-GEOD-52340 | biostudies-arrayexpress
GenomicsColon_Illumina_2.5M_Controls - samples
Colon matched tumour samples
EGAD00010000274 | EGA
GenomicsColon_Illumina_2.5M_Cases - samples
Colon tumour samples
EGAD00010000272 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:54:35:559-18 - samples
Exome capture sequencing of colon tumor/normal pairs
EGAD00001000216 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:45:02:785-17 - samples
RNA sequencing of colon tumor/normal sample pairs
EGAD00001000215 | EGA
Genomicsena-DATASET-Genentech-10-08-2012-19:36:55:498-15 - samples
Whole genome sequencing of colon samples
EGAD00001000214 | EGA
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